Evidence map›Paper›PMID 19956698›Full record

ArticleAdvances in bioinformatics2008

Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes.

Tomas Hruz, Oliver Laule, Gabor Szabo, Frans Wessendorp, Stefan Bleuler, Lukas Oertle, Peter Widmayer, Wilhelm Gruissem, Philip Zimmermann

Abstract read
In one paragraph

Article in Advances in bioinformatics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,026 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,026citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,026 citing papers in PubMed, 1 synthesis or guideline pooled it.

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966 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tomas HruzInstitute of Theoretical Computer Science, ETH Zurich, 8092 Zurich, Switzerland.
Oliver Laule
Gabor Szabo
Frans Wessendorp
Stefan Bleuler
Lukas Oertle
Peter Widmayer
Wilhelm Gruissem
Philip Zimmermann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Web-based software tool Genevestigator provides powerful tools for biologists to explore gene expression across a wide variety of biological contexts. Its first releases, however, were limited by the scaling ability of the system architecture, multiorganism data storage and analysis capability, and availability of computationally intensive analysis methods. Genevestigator V3 is a novel meta-analysis system resulting from new algorithmic and software development using a client/server architecture, large-scale manual curation and quality control of microarray data for several organisms, and curation of pathway data for mouse and Arabidopsis. In addition to improved querying features, Genevestigator V3 provides new tools to analyze the expression of genes in many different contexts, to identify biomarker genes, to cluster genes into expression modules, and to model expression responses in the context of metabolic and regulatory networks. Being a reference expression database with user-friendly tools, Genevestigator V3 facilitates discovery research and hypothesis validation.

Identifiers

PMID19956698
PMCPMC2777001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.