ArticlePLoS genetics2009
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.Molecular psychiatry · 2016Pooled it
- Pooled it
- A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.Bioinformatics (Oxford, England) · 2021Article
- Effect of population stratification on SNP-by-environment interaction.Genetic epidemiology · 2019Article
- Statistical Methods and Software for Substance Use and Dependence Genetic Research.Current genomics · 2019Review
- A multiple regression method for genomewide association studies using only linkage information.Journal of genetics · 2018Article
- On the association analysis of CNV data: a fast and robust family-based association method.BMC bioinformatics · 2017Article
- Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data.Genetic epidemiology · 2017Article
- Relevance of the COPI complex for Alzheimer's disease progression in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A powerful nonparametric statistical framework for family-based association analyses.Genetics · 2015Article
- PLD3 gene variants and Alzheimer's disease.Nature · 2015Article
- Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants.BMC bioinformatics · 2015Article
- Family-based association tests for sequence data, and comparisons with population-based association tests.European journal of human genetics : EJHG · 2013Article
- Dosage transmission disequilibrium test (dTDT) for linkage and association detection.PloS one · 2013Article
- A general framework for two-stage analysis of genome-wide association studies and its application to case-control studies.American journal of human genetics · 2012Article
- Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons.American journal of epidemiology · 2012Article
- On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies.Human heredity · 2012Article
- Family-based designs for genome-wide association studies.Nature reviews. Genetics · 2011Review
- Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.Human molecular genetics · 2011Article
- On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples.Genetic epidemiology · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditional family-based approaches that are based exclusively on the within-family information. The approach is suitable for the analysis of almost any trait type, e.g. binary, continuous, time-to-onset, multivariate, etc., and combinations of those. We use simulation studies to verify all theoretically derived properties of the approach, estimate its power, and compare it with other standard approaches. We illustrate the practical implications of the new analysis method by an application to a lung-function phenotype, forced expiratory volume in one second (FEV1) in 4 genome-wide association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.