ArticlePloS one2009
Structural plasticity can produce metaplasticity.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Trial
- Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice.Cellular and molecular neurobiology · 2024Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Synergies between synaptic and HCN channel plasticity dictates firing rate homeostasis and mutual information transfer in hippocampal model neuron.Frontiers in cellular neuroscience · 2023Article
- Degeneracy in hippocampal physiology and plasticity.Hippocampus · 2019Review
- Intracellular calcium stores mediate metaplasticity at hippocampal dendritic spines.The Journal of physiology · 2019Article
- Neuronal plasticity affects correlation between the size of dendritic spine and its postsynaptic density.Scientific reports · 2019Article
- PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex.Scientific reports · 2018Article
- Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo.Cell reports · 2018Article
- Functional consequences of pre- and postsynaptic expression of synaptic plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Mechanisms of heterosynaptic metaplasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Evidence for metaplasticity in the human visual cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects.Homeopathy : the journal of the Faculty of Homeopathy · 2013Article
- The BCM theory of synapse modification at 30: interaction of theory with experiment.Nature reviews. Neuroscience · 2012Review
- Soft-bound synaptic plasticity increases storage capacity.PLoS computational biology · 2012Article
- Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning rule.Journal of neurophysiology · 2010Article
- Neural plasticity of development and learning.Human brain mapping · 2010Review
- Postsynaptic signal transduction models for long-term potentiation and depression.Frontiers in computational neuroscience · 2010Article
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2 authors.
Funding
Abstract
backgroundSynaptic plasticity underlies many aspect of learning memory and development. The properties of synaptic plasticity can change as a function of previous plasticity and previous activation of synapses, a phenomenon called metaplasticity. Synaptic plasticity not only changes the functional connectivity between neurons but in some cases produces a structural change in synaptic spines; a change thought to form a basis for this observed plasticity. Here we examine to what extent structural plasticity of spines can be a cause for metaplasticity. This study is motivated by the observation that structural changes in spines are likely to affect the calcium dynamics in spines. Since calcium dynamics determine the sign and magnitude of synaptic plasticity, it is likely that structural plasticity will alter the properties of synaptic plasticity. METHODOLOGY/PRINCIPAL
findingsIn this study we address the question how spine geometry and alterations of N-methyl-D-aspartic acid (NMDA) receptors conductance may affect plasticity. Based on a simplified model of the spine in combination with a calcium-dependent plasticity rule, we demonstrated that after the induction phase of plasticity a shift of the long term potentiation (LTP) or long term depression (LTD) threshold takes place. This induces a refractory period for further LTP induction and promotes depotentiation as observed experimentally. That resembles the BCM metaplasticity rule but specific for the individual synapse. In the second phase, alteration of the NMDA response may bring the synapse to a state such that further synaptic weight alterations are feasible. We show that if the enhancement of the NMDA response is proportional to the area of the post synaptic density (PSD) the plasticity curves most likely return to the initial state. CONCLUSIONS/SIGNIFICANCE: Using simulations of calcium dynamics in synaptic spines, coupled with a biophysically motivated calcium-dependent plasticity rule, we find under what conditions structural plasticity can form the basis of synapse specific metaplasticity.
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