ArticlePloS one2009
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Inferring evolutionary trajectories from cross-sectional transcriptomic data to mirror lung adenocarcinoma progression.PLoS computational biology · 2023Article
- Identifying Microbiota Signature and Functional Rules Associated With Bacterial Subtypes in Human Intestine.Frontiers in genetics · 2019Article
- Tissue Expression Difference between mRNAs and lncRNAs.International journal of molecular sciences · 2018Article
- Cell Cycle Model System for Advancing Cancer Biomarker Research.Scientific reports · 2017Article
- Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method.Oncotarget · 2017Article
- Discriminating between deleterious and neutral non-frameshifting indels based on protein interaction networks and hybrid properties.Molecular genetics and genomics : MGG · 2015Article
- Prediction of antimicrobial peptides based on sequence alignment and support vector machine-pairwise algorithm utilizing LZ-complexity.BioMed research international · 2015Article
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- Discriminating between lysine sumoylation and lysine acetylation using mRMR feature selection and analysis.PloS one · 2014Article
- Prediction of S-nitrosylation modification sites based on kernel sparse representation classification and mRMR algorithm.BioMed research international · 2014Article
- Prediction of protein amidation sites by feature selection and analysis.Molecular genetics and genomics : MGG · 2013Article
- Signal propagation in protein interaction network during colorectal cancer progression.BioMed research international · 2013Article
- Classification of time series gene expression in clinical studies via integration of biological network.PloS one · 2013Article
- Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.Molecular systems biology · 2013Article
- An ensemble prognostic model for colorectal cancer.PloS one · 2013Article
- Prediction and Analysis of Post-Translational Pyruvoyl Residue Modification Sites from Internal Serines in Proteins.PloS one · 2013Article
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- Predicting drugs side effects based on chemical-chemical interactions and protein-chemical interactions.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More and more people are concerned by the risk of unexpected side effects observed in the later steps of the development of new drugs, either in late clinical development or after marketing approval. In order to reduce the risk of the side effects, it is important to look out for the possible xenobiotic responses at an early stage. We attempt such an effort through a prediction by assuming that similarities in microarray profiles indicate shared mechanisms of action and/or toxicological responses among the chemicals being compared. A large time course microarray database derived from livers of compound-treated rats with thirty-four distinct pharmacological and toxicological responses were studied. The mRMR (Minimum-Redundancy-Maximum-Relevance) method and IFS (Incremental Feature Selection) were used to select a compact feature set (141 features) for the reduction of feature dimension and improvement of prediction performance. With these 141 features, the Leave-one-out cross-validation prediction accuracy of first order response using NNA (Nearest Neighbor Algorithm) was 63.9%. Our method can be used for pharmacological and xenobiotic responses prediction of new compounds and accelerate drug development.
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