ArticlePloS one2009
Occult HCV infection: an unexpected finding in a population unselected for hepatic disease.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection.World journal of gastroenterology · 2018Trial
- Prevalence and Risk Factors of Occult HCV Infection in the Adult Population of Mexico City.Viruses · 2025Article
- Detection of hepatitis C virus (HCV) RNA in the peripheral blood mononuclear cells of HCV-infected patients following sustained virologic response.Clinical and experimental medicine · 2023Article
- Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis.World journal of methodology · 2022Article
- Occult Infection with Hepatitis C Virus: Looking for Clear-Cut Boundaries and Methodological Consensus.Journal of clinical medicine · 2021Review
- Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy.Internal medicine (Tokyo, Japan) · 2021Article
- Prevalence of occult hepatitis C virus infection in hemodialysis patients.Caspian journal of internal medicine · 2021Article
- Occult Hepatitis C Virus Infection: A Review.Journal of clinical and translational hepatology · 2018Review
- Prevalence of occult hepatitis C virus among hemodialysis patients in Tanta university hospitals: a single-center study.Environmental science and pollution research international · 2018Article
- Prevalence and risk factors of Occult Hepatitis C infections in blood donors from Mexico City.PloS one · 2018Article
- Occult HCV Infection (OCI) Diagnosis in Cirrhotic and Non-cirrhotic Naïve Patients by Intra-PBMC Nested Viral RNA PCR.Journal of clinical and translational hepatology · 2017Article
- Hepatitis C Virus RNA Strands Detection in Peripheral Blood Mononuclear Cells Legitimizes Virus Eradication in Negative Serum PCR Naïve and Post-treatment Patients.Journal of clinical and translational hepatology · 2017Article
- Article
- Occult Hepatitis C Virus Infection in Hemodialysis Patients; Single Center Study.Electronic physician · 2015Article
- Occult HCV Infection: The Current State of Knowledge.Iranian Red Crescent medical journal · 2015Review
- Epidemiology of hepatitis C virus in Iran.World journal of gastroenterology · 2015Review
- Article
- A New Twist to a Chronic HCV Infection: Occult Hepatitis C.Gastroenterology research and practice · 2015Review
- Seronegative hepatitis C virus infection.Archivum immunologiae et therapiae experimentalis · 2014Review
- Occult hepatitis C virus infection in candidates for liver transplant with cryptogenic cirrhosis.Hepatitis monthly · 2013Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOccult Hepatitis C virus (HCV) infection is a new pathological entity characterized by presence of liver disease and absence or very low levels of detectable HCV-RNA in serum. Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a population unselected for hepatic disease. METHODOLOGY/PRINCIPAL
findingsWe chose from previous epidemiological studies three series of subjects (n = 276, age range 40-65 years) unselected for hepatic disease. These subjects were tested for the presence of HCV antibodies and HCV-RNA in plasma and in the peripheral blood mononuclear cells (PBMCs) by using commercial systems. All subjects tested negative for HCV antibodies and plasma HCV-RNA and showed normal levels of liver enzymes; 9/276 patients (3.3%) were positive for HCV-RNA in PBMCs, identifying a subset of subjects with potential occult HCV infection. We could determine the HCV type for 8 of the 9 patients finding type 1a (3 patients), type 1b (2 patients), and type 2a (3 patients).
conclusionsThe results of this study show evidence that occult HCV infection may occur in a population unselected for hepatic disease. A potential risk of HCV infection spread by subjects harbouring occult HCV infection should be considered. Design of prospective studies focusing on the frequency of infection in the general population and on the clinical evolution of occult HCV infection will be needed to verify this unexpected finding.
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