Evidence map›Paper›PMID 19956426›Full record

ArticleAmerican journal of translational research2009

Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease.

Whitney Wharton, Carey E Gleason, Katelin R Lorenze, Tamara S Markgraf, Michele L Ries, Cynthia M Carlsson, Sanjay Asthana

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  16. Hormone replacement therapy and risk for neurodegenerative diseases.International journal of Alzheimer's disease · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Whitney Wharton
Carey E Gleason
Katelin R Lorenze
Tamara S Markgraf
Michele L Ries
Cynthia M Carlsson
Sanjay Asthana

Funding

KEEPS Cognitive and Affective StudyR01AG029624 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ASTHANA, SANJAY · 2007 to 2013
$3.4M
Effect of Statins on Pathobiology of Alzheimer's DiseaseK23AG026752 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CARLSSON, CYNTHIA M · 2005 to 2008
$756k
Alzheimer's Disease: Potential Benefit of IsoflavonesK23AG024302 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI GLEASON, CAREY E · 2004 to 2008
$661k
NIA Academic Career Leadership Award in Alzheimer's DiseaseK07AG021582 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ASTHANA, SANJAY · 2006 to 2010
$540k
NIA NIH HHS K07 AG021582NIA NIH HHS K23 AG024302NIA NIH HHS K23 AG026752NIA NIH HHS R01 AG029624
6 · The paper itself

Abstract

Over a decade of converging findings from clinical, observational and basic science research indicate that estrogen administration during the menopausal transition exerts beneficial effects on cognition and decreases a woman's risk of developing Alzheimer's disease (AD) later in life. This review article stresses the research focus of AD prevention, and introduces hormone therapy (HT) as a probable catalyst that may achieve this goal. Furthermore, this article outlines 3 mechanisms proposed to mediate estrogen's beneficial effects, discusses the controversy surrounding HT administration, and presents the most promising estrogen related research in AD prevention and treatment. Although controversial, cumulative evidence suggests that the potential of estrogen initiated during perimenopause to prevent AD needs to be systematically evaluated.

Indexed as

Alzheimer's diseasecognitionEstrogenestrogen therapyhormone therapypostmenopausal cognitionwomen's health initiative

Identifiers

PMID19956426
PMCPMC2776312
OpenAlexW106280853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.