ArticleTranslational oncology2009
PET/CT Assessment of Response to Therapy: Tumor Change Measurement, Truth Data, and Error.
Article in Translational oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Measurement of metabolic activity by telemetric temperature sensing after immunotherapy and chemotherapy on three different mouse tumor models.BMC cancer · 2026Article
- The implication of aberrant NRF2 activation in management of female cancers.Frontiers in oncology · 2025Review
- A spatiotemporal multi-scale computational model for FDG PET imaging at different stages of tumor growth and angiogenesis.Scientific reports · 2022Article
- Tumor Size Measurements for Predicting Hodgkin's and Non-Hodgkin's Lymphoma Response to Treatment.Metabolites · 2022Article
- New standards for phantom image quality and SUV harmonization range for multicenter oncology PET studies.Annals of nuclear medicine · 2022Article
- PET NEMA IQ Phantom dataset: image reconstruction settings for quantitative PET imaging.Data in brief · 2021Article
- Principal Component Analysis of Simultaneous PET-MRI Reveals Patterns of Bone-Cartilage Interactions in Osteoarthritis.Journal of magnetic resonance imaging : JMRI · 2020Article
- An account of data entry inconsistencies and their impact on positron emission tomography quantification.Medicine · 2018Article
- The public cancer radiology imaging collections of The Cancer Imaging Archive.Scientific data · 2017Article
- Longitudinal monitoring of reconstructed activity concentration on a clinical time-of-flight PET/CT scanner.Journal of medical imaging (Bellingham, Wash.) · 2017Article
- Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography.Journal of medical imaging (Bellingham, Wash.) · 2017Article
- Biomechanical model for computing deformations for whole-body image registration: A meshless approach.International journal for numerical methods in biomedical engineering · 2016Article
- Evaluation of Cross-CalibratedTomography (Ann Arbor, Mich.) · 2016Article
- Primary lung tumor segmentation from PET-CT volumes with spatial-topological constraint.International journal of computer assisted radiology and surgery · 2016Article
- Multimodality molecular imaging of the lung.Clinical and translational imaging · 2014Article
- Article
- Combined Injection of (18)F-Fluorodeoxyglucose and 3'-Deoxy-3'-[(18)F]fluorothymidine PET Achieves More Complete Identification of Viable Lung Cancer Cells in Mice and Patients than Individual Radiopharmaceutical: A Proof-of-Concept Study.Translational oncology · 2013Article
- Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings.Clinical nuclear medicine · 2013Article
- Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials.Magnetic resonance imaging · 2012Article
- Superior prognostic utility of gross and metabolic tumor volume compared to standardized uptake value using PET/CT in head and neck squamous cell carcinoma patients treated with intensity-modulated radiotherapy.Annals of nuclear medicine · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We describe methods and issues that are relevant to the measurement of change in tumor uptake of (18)F-fluorodeoxyglucose (FDG) or other radiotracers, as measured from positron emission tomography/computed tomography (PET/CT) images, and how this would relate to the establishment of PET/CT tumor imaging as a biomarker of patient response to therapy. The primary focus is on the uptake of FDG by lung tumors, but the approach can be applied to diseases other than lung cancer and to tracers other than FDG. The first issue addressed is the sources of bias and variance in the measurement of tumor uptake of FDG, and where there are still gaps in our knowledge. These are discussed in the context of measurement variation and how these would relate to the early detection of response to therapy. Some of the research efforts currently underway to identify the magnitude of some of these sources of error are described. In addition, we describe resources for these investigations that are being made available through the Reference Image Database for the Evaluation of Response project. Measures derived from PET image data that might be predictive of patient response as well as the additional issues that each of these metrics may encounter are described briefly. The relationship between individual patient response to therapy and utility for multicenter trials is discussed. We conclude with a discussion of moving from assessing measurement variation to the steps necessary to establish the efficacy of PET/CT imaging as a biomarker for response.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.