Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Trial
- Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment.The American journal of psychiatry · 2016Trial
- Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia.JAMA psychiatry · 2015Trial
- Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Personalized prediction of treatment response during the acute phase of schizophrenia based on the connectome-based predictive model.European archives of psychiatry and clinical neuroscience · 2026Article
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential.Journal of psychopharmacology (Oxford, England) · 2026Review
- Resting-state connectivity and tobacco smoking in clinical high-risk for psychosis (NAPLS-3).General psychiatry · 2026Article
- MesoSCOUT: A novel tool for revealing mesoscale organization in the white-matter connectome.bioRxiv : the preprint server for biology · 2025Article
- COMPLEX-VALUED PHASE SYNCHRONY REVEALS DIRECTIONAL COUPLING IN FMRI AND TRACKS MEDICATION EFFECTS.ArXiv · 2025Article
- Prediction of Clinical Outcomes in Psychotic Disorders Using Artificial Intelligence Methods: A Scoping Review.Brain sciences · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study.Frontiers in pharmacology · 2024Article
- Increased Functional Connectivity Involving the Parahippocampal Gyrus in Patients with Schizophrenia during Theory of Mind Processing: A Psychophysiological Interaction Study.Brain sciences · 2023Article
- Article
- Multimodal brain deficits shared in early-onset and adult-onset schizophrenia predict positive symptoms regardless of illness stage.Human brain mapping · 2022Article
- Predicting Treatment Response in Schizophrenia With Magnetic Resonance Imaging and Polygenic Risk Score.Frontiers in genetics · 2022Article
- Graph-Theory-Based Degree Centrality Combined with Machine Learning Algorithms Can Predict Response to Treatment with Antipsychotic Medications in Patients with First-Episode Schizophrenia.Disease markers · 2022Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Earlier studies have shown widespread alterations of functional connectivity of various brain networks in schizophrenia, including the default mode network (DMN). The DMN has also an important role in the performance of cognitive tasks. Furthermore, treatment with second-generation antipsychotic drugs may ameliorate to some degree working memory (WM) deficits and related brain activity. The aim of this study was to evaluate the effects of treatment with olanzapine monotherapy on functional connectivity among brain regions of the DMN during WM. Seventeen patients underwent an 8-week prospective study and completed two functional magnetic resonance imaging (fMRI) scans at 4 and 8 weeks of treatment during the performance of the N-back WM task. To control for potential repetition effects, 19 healthy controls also underwent two fMRI scans at a similar time interval. We used spatial group-independent component analysis (ICA) to analyze fMRI data. Relative to controls, patients with schizophrenia had reduced connectivity strength within the DMN in posterior cingulate, whereas it was greater in precuneus and inferior parietal lobule. Treatment with olanzapine was associated with increases in DMN connectivity with ventromedial prefrontal cortex, but not in posterior regions of DMN. These results suggest that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia. In addition, our findings suggest critical functional differences in the regions of DMN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.