ArticleJournal of endocrinological investigation2010
Prevalence of double pituitary adenomas in a surgical series: Clinical, histological and genetic features.
Article in Journal of endocrinological investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Double pituitary adenomas: report of two cases and systematic review of the literature.Frontiers in endocrinology · 2024Pooled it
- Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.Pituitary · 2017Pooled it
- Clinical management challenges of Cushing's disease associated with double pituitary adenomas: four cases and literature review.Endocrine · 2026Review
- Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review.Journal of biomedical optics · 2025Review
- Article
- Double PitNETs: A Case Report and Literature Review.Cancers · 2025Review
- Typical morphological characteristics of the immunohistochemical subtypes of pituitary microadenomas: a dual center study.Endocrine connections · 2024Article
- Consecutive resections of double pituitary adenoma for resolution of Cushing disease: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Concurrent IgG4-related hypophysitis and clinically nonfunctioning gonadotroph pituitary neuroendocrine tumor.BMC endocrine disorders · 2023Article
- Double pituitary neuroendocrine tumors in a patient with normal growth hormone level acromegaly: A case report and review of the literature.Surgical neurology international · 2023Article
- A Collision Tumor of Pit-1/SF-1-positive Double Pituitary Adenoma and a Craniopharyngioma Coexisting with Graves' Disease.NMC case report journal · 2023Article
- Expressions of Cushing's syndrome in multiple endocrine neoplasia type 1.Frontiers in endocrinology · 2023Review
- Article
- Metachronous Double Pituitary Adenoma with Altered Transcriptional Factor Profile: A Case Report and Literature Review.NMC case report journal · 2021Article
- Double pituitary adenomas in a large surgical series.Pituitary · 2019Article
- The causes and consequences of pituitary gigantism.Nature reviews. Endocrinology · 2018Review
- Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.Endocrine pathology · 2018Article
- Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical Challenges and the Family Members' View in anInternational journal of endocrinology · 2018Article
- An unusual case of Cushing's syndrome due to bihormonal ACTH-prolactin secreting pituitary macroadenoma with rapid response to cabergoline.BMJ case reports · 2017Article
- Double separate versus contiguous pituitary adenomas: MRI features and endocrinological follow up.Pituitary · 2016Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe term double pituitary adenomas (DPA) is usually referred to those rare lesions showing two distinct cellular components. Genetic background may sustain the proliferation of more than one cell at the same time but no information is available on the presence of aip mutations in these patients.
aimWe report the prevalence and the endocrinological, neuroradiological, histopathological and genetic features of DPA detected in a large surgical series. The contribution of pituitary transcription factor immunostains in DPA was also evaluated. SUBJECTS AND
methodsOne-hundred-forty-four patients undergoing surgery for tumors of the sellar region were evaluated. Histopathology, immunohistochemistry and the mutational analysis for the entire coding region of the AIP and MEN1 genes were performed.
resultsOne-hundred-seventeen patients out of 144 had a pituitary adenoma. DPA was found in 3 (2.6%) out of 117 patients with pituitary adenoma. Immunohistochemistry and transcription factors analysis demonstrated two not yet described histotype associations in DPA. The coexistence of somatotroph-lactotroph and silent mammosomatotroph histotype in 1 case and the coexistence of sparsely granulated lactotroph and null cell adenomas in the remaining two cases were first identified. Sequencing data for the coding region of the aip and the menin gene resulted in wild type sequences in all patients with DPA.
conclusionsThe prevalence of DPA observed in our unselected surgical series is not negligible (2.6%). Furthermore, the evaluation of the treatment outcome would suggest that the clinical management of DPAs requires a careful diagnostic approach and follow- up.
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