Trial reportCerebrovascular diseases (Basel, Switzerland)2010
Relationship between non-specific prescription pill adherence and ischemic stroke outcomes.
Trial report in Cerebrovascular diseases (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Statins for Primary Prevention of Cardiovascular Disease in Elderly Patients: Systematic Review and Meta-Analysis.Drugs & aging · 2015 · on this mapPooled it
- Pharmacist intervention for blood pressure control: medication intensification and adherence.Journal of the American Society of Hypertension : JASH · 2015Trial
- Persistence of drug therapy is associated with ischemic stroke and other vascular events in high-risk stroke population.Frontiers in neurology · 2022Article
- Antihypertensive agent utilization patterns among patients with uncontrolled hypertension in the United States.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Poor drug adherence and lack of awareness of hypertension among hypertensive stroke patients in Kampala, Uganda: a cross sectional study.BMC research notes · 2016Article
- A new model for secondary prevention of stroke: transition coaching for stroke.Frontiers in neurology · 2014Review
- Impact of a better persistence with antihypertensive agents on ischemic stroke outcomes for secondary prevention.PloS one · 2013Article
- Adherence to antihypertensive agents after ischemic stroke and risk of cardiovascular outcomes.Neurology · 2012Article
- All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts.World review of nutrition and dietetics · 2011Article
- [Compliance with recommendations in secondary prevention of stroke in primary care].Atencion primariaArticle
- Self-reported barriers to medication use in older women: Findings from the Women's Health Initiative.Journal of the American Pharmacists Association : JAPhAArticle
- Medication adherence and stroke/TIA risk in treated hypertensives: results from the REGARDS study.Journal of the American Society of Hypertension : JASHArticle
- Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus, and/or hypertension.Research in social & administrative pharmacy : RSAPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdherence to non-specific prescription therapy may be associated with clinical outcomes beyond a given treatment effect. We assessed the association of blinded randomized pill prescription adherence with vascular outcomes after ischemic stroke.
methodsWe analyzed the Vitamin Intervention for Stroke Prevention (VISP) study database. VISP was a double-blind randomized trial, designed to determine whether high doses of vitamins (vs. low doses) would reduce recurrent stroke risk in 3,680 participants over a 2-year period. We examined the independent association of adherence with a composite endpoint (stroke, myocardial infarction, death).
resultsAmong 3,357 (91%) subjects with complete data, women, non-White persons, current smokers, those not on statins and those without a history of coronary artery bypass surgery were significantly less likely to be optimally adherent. Over the trial, persons who adhered well to treatment were less likely to experience the combined outcome than those who adhered poorly (13.4 vs. 20.6%, p < 0.0001). After multivariable analysis using various adherence measures, there were no significant differences between >or=80% vs. <80% adherence, but compared to <65% adherence, pill adherence levels of >or=90 to <99% (HR 0.56, 95% CI = 0.34-0.91; p = 0.02) and >or=99% (HR 0.46, 95% CI = 0.29-0.73; p = 0.001) were associated with lower occurrence of the combined outcome at 18 months.
conclusionsLong-term excellent adherence to non-specific pill prescription among ischemic stroke patients is independently associated with lower vascular risk, and is likely a marker of overall healthy behavior that may be helpful in targeting stroke patients with unhealthy practices.
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