ArticleThe Journal of biological chemistry2010
PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Transcriptomics and proteomics reveals the potential mechanisms of hydroquinone-inhibited erythroid differentiation in K562 cells.Toxicology research · 2025Article
- Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages.Epigenetics & chromatin · 2024Article
- A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm.The Journal of experimental medicine · 2022Article
- A novel method for generating glutamatergic SH-SY5Y neuron-like cells utilizing B-27 supplement.Frontiers in pharmacology · 2022Article
- Article
- Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.Genome biology · 2021Article
- The shifting shape and functional specializations of the cell cycle during lineage development.WIREs mechanisms of disease · 2021Review
- Lnc-UCID Promotes G1/S Transition and Hepatoma Growth by Preventing DHX9-Mediated CDK6 Down-regulation.Hepatology (Baltimore, Md.) · 2019Article
- Article
- CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation.Oncogene · 2016Review
- PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation.Journal of hematology & oncology · 2016Article
- Positive feedback between PU.1 and the cell cycle controls myeloid differentiation.Science (New York, N.Y.) · 2013Article
- Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.Experimental hematology · 2013Article
- H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53.Stem cells (Dayton, Ohio) · 2012Article
- Article
- Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance.Cancer research · 2011Article
- Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment.Molecular and cellular biology · 2011Article
- A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell proliferation and differentiation are highly coordinated processes during normal development. Most leukemia cells are blocked from undergoing terminal differentiation and also exhibit uncontrolled proliferation. Dysregulated expression of transcription factor PU.1 is strongly associated with Friend virus-induced erythroleukemia. PU.1 inhibits erythroid differentiation by binding to and inhibiting GATA-1. PU.1 also may be involved in controlling proliferation of erythroid cells. We reported previously that the G(1) phase-specific cyclin-dependent kinase 6 (CDK6) also blocks erythroid differentiation. We now report that PU.1 directly stimulates transcription of the cdk6 gene in both normal erythroid progenitors and erythroleukemia cells, as well as in macrophages. We propose that PU.1 coordinates proliferation and differentiation in immature erythroid cells by inhibiting the GATA-1-mediated gene expression program and also by regulating expression of genes that control progression through the G(1) phase of the cell cycle, the period during which the decision to differentiate is made.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.