ArticleThe New England journal of medicine2009
Forecasting the effects of obesity and smoking on U.S. life expectancy.
Article in The New England journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01800591 (UPHS Weight Loss Study), which is not on this map. Cited by 184 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
UPHS Weight Loss Study: Evaluating Methods to Use Health Benefits Design to Encourage Employee Weight Loss
Who cites it
184 citing papers in PubMed, 4 syntheses or guidelines pooled it, 473 citations in OpenAlex.
- Weight reduction and the impact on apnea-hypopnea index: A systematic meta-analysis.Sleep medicine · 2024Pooled it
- A developmental cascade perspective of paediatric obesity: A systematic review of preventive interventions from infancy through late adolescence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Guideline
- European guidelines on cardiovascular disease prevention in clinical practice (version 2012) : the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts).International journal of behavioral medicine · 2012Guideline
- Patient-provided e-support in reduced intensity obesity treatment: The INSPIRE randomized controlled trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Trial
- Trial
- Outcomes of an early childhood obesity prevention program in a low-income community: a pilot, randomized trial.Pediatric obesity · 2018Trial
- Evaluation of Post Cessation Weight Gain in a 1-Year Randomized Smoking Cessation Trial of Electronic Cigarettes.Scientific reports · 2016Trial
- Naltrexone reduction of long-term smoking cessation weight gain in women but not men: a randomized controlled trial.Biological psychiatry · 2013Trial
- Individual- versus group-based financial incentives for weight loss: a randomized, controlled trial.Annals of internal medicine · 2013Trial
- Effects of naltrexone on smoking cessation outcomes and weight gain in nicotine-dependent men and women.Journal of clinical psychopharmacology · 2012Trial
- Changes in body weight and food choice in those attempting smoking cessation: a cluster randomised controlled trial.BMC public health · 2012Trial
- Effect of the look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes.Diabetes care · 2010Trial
- SerpinA3N in leptin-sensitive neurons is required for energy and glucose homeostasis and autonomic regulation.Metabolism: clinical and experimental · 2025Article
- The association between daily movement behavior and adjusted handgrip strength in post-menopausal women.Frontiers in nutrition · 2025Article
- Article
- Possible muscle-sparing advantage and bodyweight maintenance of laparoscopic gastrectomy for older patients with locally advanced gastric cancer.Langenbeck's archives of surgery · 2024Article
- Bidirectional relationships between nicotine vaping and maladaptive eating behaviors among young adults.Addictive behaviors reports · 2024Article
- Estimated Savings After Stopping Tyrosine Kinase Inhibitor Treatment Among Patients With Chronic Myeloid Leukemia.JAMA network open · 2023Article
- Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals.Nature communications · 2023Article
124 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough increases in obesity over the past 30 years have adversely affected the health of the U.S. population, there have been concomitant improvements in health because of reductions in smoking. Having a better understanding of the joint effects of these trends on longevity and quality of life will facilitate more efficient targeting of health care resources.
methodsFor each year from 2005 through 2020, we forecasted life expectancy and quality-adjusted life expectancy for a representative 18-year-old, assuming a continuation of past trends in smoking (based on data from the National Health Interview Survey for 1978 through 1979, 1990 through 1991, 1999 through 2001, and 2004 through 2006) and past trends in body-mass index (BMI) (based on data from the National Health and Nutrition Examination Survey for 1971 through 1975, 1988 through 1994, 1999 through 2002, and 2003 through 2006). The 2003 Medical Expenditure Panel Survey was used to examine the effects of smoking and BMI on health-related quality of life.
resultsThe negative effects of increasing BMI overwhelmed the positive effects of declines in smoking in multiple scenarios. In the base case, increases in the remaining life expectancy of a typical 18-year-old are held back by 0.71 years or 0.91 quality-adjusted years between 2005 and 2020. If all U.S. adults became nonsmokers of normal weight by 2020, we forecast that the life expectancy of an 18-year-old would increase by 3.76 life-years or 5.16 quality-adjusted years.
conclusionsIf past obesity trends continue unchecked, the negative effects on the health of the U.S. population will increasingly outweigh the positive effects gained from declining smoking rates. Failure to address continued increases in obesity could result in an erosion of the pattern of steady gains in health observed since early in the 20th century.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.