ArticleProceedings of the National Academy of Sciences of the United States of America2009
Calcium participates in feedback regulation of the oscillating ROP1 Rho GTPase in pollen tubes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 77 citations in OpenAlex.
- TipQuant: a robust algorithm for quantitative analysis of spatiotemporally dynamic activities in tip-growing cells.The New phytologist · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate.Plants (Basel, Switzerland) · 2021Article
- Hyperoside promotes pollen tube growth by regulating the depolymerization effect of actin-depolymerizing factor 1 on microfilaments in okra.Horticulture research · 2021Article
- The quest for the central players governing pollen tube growth and guidance.Plant physiology · 2021Review
- Signalling Pinpointed to the Tip: The Complex Regulatory Network That Allows Pollen Tube Growth.Plants (Basel, Switzerland) · 2020Review
- Fertilization in flowering plants: an odyssey of sperm cell delivery.Plant molecular biology · 2020Review
- Exocytosis and endocytosis: coordinating and fine-tuning the polar tip growth domain in pollen tubes.Journal of experimental botany · 2020Review
- Spatiotemporal dynamics of a reaction-diffusion model of pollen tube tip growth.Journal of mathematical biology · 2019Article
- Autonomous microfluidic actuators for periodic sequential flow generation.Science advances · 2019Article
- Actin Cytoskeleton as Actor in Upstream and Downstream of Calcium Signaling in Plant Cells.International journal of molecular sciences · 2019Review
- The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes.Nature communications · 2018Article
- Simultaneous imaging and functional studies reveal a tight correlation between calcium and actin networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Elongation and shape changes in organisms with cell walls: A dialogue between experiments and models.Cell surface (Amsterdam, Netherlands) · 2018Review
- Light Sheet Fluorescence Microscopy Quantifies Calcium Oscillations in Root Hairs of Arabidopsis thaliana.Plant & cell physiology · 2017Article
- Spermine Regulates Pollen Tube Growth by Modulating CaFrontiers in plant science · 2017Article
- Arabidopsis JINGUBANG Is a Negative Regulator of Pollen Germination That Prevents Pollination in Moist Environments.The Plant cell · 2016Article
- Multiple independent autonomous hydraulic oscillators driven by a common gravity head.Nature communications · 2015Article
- Focusing on the focus: what else beyond the master switches for polar cell growth?Molecular plant · 2015Review
- No stress! Relax! Mechanisms governing growth and shape in plant cells.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Biological oscillation occurs at various levels, from cellular signaling to organismal behaviors. Mathematical modeling has allowed a quantitative understanding of slow oscillators requiring changes in gene expression (e.g., circadian rhythms), but few theoretical studies have focused on the rapid oscillation of cellular signaling. The tobacco pollen tube, which exhibits growth bursts every 80 s or so, is an excellent system for investigating signaling oscillation. Pollen tube growth is controlled by a tip-localized ROP1 GTPase, whose activity oscillates in a phase about 90 degrees ahead of growth. We constructed a mathematical model of ROP1 activity oscillation consisting of interlinking positive and negative feedback loops involving F-actin and calcium, ROP1-signaling targets that oscillate in a phase about 20 degrees and 110 degrees behind ROP1 activity, respectively. The model simulates the observed changes in ROP1 activity caused by F-actin disruption and predicts a role for calcium in the negative feedback regulation of the ROP1 activity. Our experimental data strongly support this role of calcium in tip growth. Thus, our findings provide insight into the mechanism of pollen tube growth and the oscillation of cellular signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.