Evidence map›Paper›PMID 19955237›Full record

ArticleBriefings in bioinformatics2010

Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology.

Peter D Karp, Suzanne M Paley, Markus Krummenacker, Mario Latendresse, Joseph M Dale, Thomas J Lee, Pallavi Kaipa, Fred Gilham, Aaron Spaulding, Liviu Popescu and 4 more

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

248 citing papers in PubMed.

  1. Article
  2. BioMark: biomarker analysis tool.BMC bioinformatics · 2026
    Article
  3. Constraint-Based Metabolic Modeling Approach for Microbial Communities.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. Proteomic profiling of zinc homeostasis mechanisms inbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Frontiers in plant science · 2023
    Article
  20. Biochemical Insights into the Ability ofPlants (Basel, Switzerland) · 2022
    Article

188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Peter D KarpArtificial Intelligence Center, SRI International, 333 Ravenswood Ave, AE206, Menlo Park, CA 94025, USA. pkarp@ai.sri.com
Suzanne M Paley
Markus Krummenacker
Mario Latendresse
Joseph M Dale
Thomas J Lee
Pallavi Kaipa
Fred Gilham
Aaron Spaulding
Liviu Popescu
Tomer Altman
Ian Paulsen
Ingrid M Keseler
Ron Caspi

Funding

The MetaCyc & BioCyc Pathway/Genome Databases (SRI Proposal ECU 14-630)R01GM080746 · NIGMS · SRI INTERNATIONAL · PI CASPI, RON, KARP, PETER D · 2007 to 2021
$15.6M
The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
Robust Software Components for Model Organism DatabasesR01GM075742 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2005 to 2019
$12.0M
The EcoCyc Model Organism Database for Escherichia coliR01GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2019 to 2022
$4.6M
Pathway Prediction and Assessment Integrating Multiple Evidence TypesR01LM009651 · NLM · SRI INTERNATIONAL · PI KARP, PETER D · 2007 to 2009
$525k
NIGMS NIH HHS GM077678NIGMS NIH HHS GM080746NIGMS NIH HHS GM75742NIGMS NIH HHS R01 GM075742NIGMS NIH HHS R01 GM077678NIGMS NIH HHS R01 GM080746NIGMS NIH HHS U24 GM077678NLM NIH HHS LM009651NLM NIH HHS R01 LM009651
6 · The paper itself

Abstract

Pathway Tools is a production-quality software environment for creating a type of model-organism database called a Pathway/Genome Database (PGDB). A PGDB such as EcoCyc integrates the evolving understanding of the genes, proteins, metabolic network and regulatory network of an organism. This article provides an overview of Pathway Tools capabilities. The software performs multiple computational inferences including prediction of metabolic pathways, prediction of metabolic pathway hole fillers and prediction of operons. It enables interactive editing of PGDBs by DB curators. It supports web publishing of PGDBs, and provides a large number of query and visualization tools. The software also supports comparative analyses of PGDBs, and provides several systems biology analyses of PGDBs including reachability analysis of metabolic networks, and interactive tracing of metabolites through a metabolic network. More than 800 PGDBs have been created using Pathway Tools by scientists around the world, many of which are curated DBs for important model organisms. Those PGDBs can be exchanged using a peer-to-peer DB sharing system called the PGDB Registry.

Indexed as

Computational BiologyGenomeSoftwareSystems BiologyInternet

Identifiers

PMID19955237
PMCPMC2810111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.