ReviewThe Journal of nutritional biochemistry2010
Antiobesity mechanisms of action of conjugated linoleic acid.
Review in The Journal of nutritional biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02529046 (Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women), which is not on this map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials.The American journal of clinical nutrition · 2012Pooled it
- Trial
- Trial
- Kefir drink leads to a similar weight loss, compared with milk, in a dairy-rich non-energy-restricted diet in overweight or obese premenopausal women: a randomized controlled trial.European journal of nutrition · 2016Trial
- Conjugated Linoleic Acid Supplementation has no Impact on Aerobic Capacity of Healthy Young Men.Lipids · 2015Trial
- Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome.European journal of clinical nutrition · 2011Trial
- Effects of linoleic acid and its trans-10 biohydrogenation intermediates (trans-10, cis-12 conjugated linoleic acid and trans-10 18:1) on lipogenic gene expression and Δ9-desaturation indices in bovine intramuscular adipocytes.Journal of animal science · 2026Article
- 2024 Clinical Practice Guidelines for the Diagnosis and Pharmacologic Treatment of Overweight and Obesity by the Korean Society for the Study of Obesity.Journal of obesity & metabolic syndrome · 2025Review
- Emerging Nanonutraceuticals against Obesity.Small science · 2025Review
- The Dual Role of Conjugated Linoleic Acid in Obesity and Metabolic Disorders.Food science & nutrition · 2025Review
- Western Diet and fecal microbiota transplantation alter phenotypic, liver fatty acids, and gut metagenomics and metabolomics in Mtarc2 knockout mice.Genes & nutrition · 2025Article
- Mode and Mechanism of Action of Omega-3 and Omega-6 Unsaturated Fatty Acids in Chronic Diseases.Nutrients · 2025Review
- Enhancing Bone Health with Conjugated Linoleic Acid: Mechanisms, Challenges, and Innovative Strategies.Nutrients · 2025Review
- Immature Citrus unshiu fruit extracts inhibit adipogenesis in 3T3-L1 adipocytes via AMPK and MAPK signaling pathways.PloS one · 2025Article
- Dairy intake and cardiovascular diseases risk factors: a cross-sectional study on Iranian obese and overweight women.BMC public health · 2024Article
- Developmentally programmed obesity: Is there a role for anti-inflammatory nutritional strategies?Experimental physiology · 2024Review
- Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals.Nutrients · 2023Article
- Review
- The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain.Frontiers in nutrition · 2023Review
- Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome.International journal of molecular sciences · 2022Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.