ReviewNeuroscience and biobehavioral reviews2010
Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.
Review in Neuroscience and biobehavioral reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Questioning the role of palmitoylethanolamide in psychosis: a systematic review of clinical and preclinical evidence.Frontiers in psychiatry · 2023Pooled it
- Disturbances in reality testing as markers of risk in offspring of parents with bipolar disorder: a systematic review from a developmental psychopathology perspective.Bipolar disorders · 2013Pooled it
- Exploratory eye movement characteristics to aid screening of schizophrenia and bipolar disorder: A cross-sectional outpatient study.Scientific reports · 2026Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- The impact of neurological and cerebellar soft signs on psychosocial functioning in bipolar disorder.Frontiers in psychiatry · 2025Article
- Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study.Schizophrenia research · 2024Article
- Subfield-specific longitudinal changes of hippocampal volumes in patients with early-stage bipolar disorder.Bipolar disorders · 2023Article
- Observational
- Niacin Skin Flush Backs-From the Roots of the Test to Nowadays Hope.Journal of clinical medicine · 2023Review
- When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants.Frontiers in psychiatry · 2023Article
- Graph Analysis of Verbal Fluency Tests in Schizophrenia and Bipolar Disorder.Brain sciences · 2022Article
- Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes.Frontiers in genetics · 2022Article
- Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia.International journal of bipolar disorders · 2021Article
- Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.Schizophrenia research · 2020Article
- Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study.NeuroImage. Clinical · 2020Article
- Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.The British journal of psychiatry : the journal of mental science · 2018Article
- Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder.International journal of bipolar disorders · 2018Article
- Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science.BMC psychiatry · 2018Article
- Brain bioenergetics and redox state measured bySchizophrenia research · 2017Article
- Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls.Schizophrenia bulletin · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping symptom dimensions, neurophysiology, genetics and treatment responses. Recent large scale genetic studies have produced inconsistent findings and exposed an urgent need for re-thinking phenomenology-based approach in psychiatric research. Epidemiological, linkage and molecular genetic studies, as well as studies in intermediate phenotypes (neurocognitive, neurophysiological and anatomical imaging) in schizophrenia and bipolar disorders are reviewed in order to support a dimensional conceptualization of psychosis. Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.