ArticleBMC genomics2009
Robustness of transcriptional regulatory program influences gene expression variability.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Transcriptomic analysis reveals the rareness of genetic assimilation of gene expression in environmental adaptations.Science advances · 2023Article
- FOXK2 transcription factor and its roles in tumorigenesis (Review).Oncology letters · 2022Review
- Resilience, plasticity and robustness in gene expression during aging in the brain of outbred deer mice.BMC genomics · 2021Article
- Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava.Scientific reports · 2021Article
- The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Multiplexed Gene Expression Tuning with Orthogonal Synthetic Gene Circuits.ACS synthetic biology · 2020Article
- A set of AP2-like genes is associated with inflorescence branching and architecture in domesticated rice.Journal of experimental botany · 2019Article
- Functional redundancy of transcription factors explains why most binding targets of a transcription factor are not affected when the transcription factor is knocked out.BMC systems biology · 2015Article
- Identifying aging-related genes in mouse hippocampus using gateway nodes.BMC systems biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost genes are not affected when any transcription factor (TF) is knocked out, indicating that they have robust transcriptional regulatory program. Yet the mechanism underlying robust transcriptional regulatory program is less clear.
resultsHere, we studied the cause and effect of robust transcriptional regulatory program. We found that cooperative TFs in the robust transcriptional regulatory program regulate their common target genes in an activity-redundant fashion, and they are able to compensate for each other's loss. As a result, their target genes are insensitive to their single perturbation. We next revealed that the degree of robustness of transcriptional regulatory program influences gene expression variability. Genes with fragile (unrobust) transcriptional regulatory program under normal growth condition could be readily reprogrammed to significantly modulate gene expression upon changing conditions. They also have high evolutionary rates of gene expression. We further showed that the fragile transcriptional regulatory program is a major source of expression variability.
conclusionWe showed that activity-redundant TFs guarantee the robustness of transcriptional regulatory programs, and the fragility of transcriptional regulatory program plays a major role in gene expression variability. These findings reveal the mechanisms underlying robust transcription and expression variability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.