ReviewProteomics2010
Label-free detection techniques for protein microarrays: prospects, merits and challenges.
Review in Proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Target identification of natural products in cancer with chemical proteomics and artificial intelligence approaches.Cancer biology & medicine · 2025Review
- A comprehensive review of transduction methods of lectin-based biosensors in biomedical applications.Heliyon · 2024Review
- Fluorescence-Based Protein Stability Monitoring-A Review.International journal of molecular sciences · 2024Review
- Highly sensitive label-free biosensor: graphene/CaFScientific reports · 2023Article
- Plasmon- and Waveguide-Coupled Fluorescence at the Ultraviolet Region.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Article
- Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions.Sensors (Basel, Switzerland) · 2022Article
- A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection.Microsystems & nanoengineering · 2021Article
- Label-free capacitive assaying of biomarkers for molecular diagnostics.Nature protocols · 2020Article
- Electrospun Nanofibers for Label-Free Sensor Applications.Sensors (Basel, Switzerland) · 2019Review
- Label-free tomography of living cellular nanoarchitecture using hyperspectral self-interference microscopy.Biomedical optics express · 2019Article
- Towards Portable Nanophotonic Sensors.Sensors (Basel, Switzerland) · 2019Review
- Label-Free Capacitive Biosensor for Detection ofSensors (Basel, Switzerland) · 2019Article
- Dual-Mode Electro-Optical Techniques for Biosensing Applications: A Review.Sensors (Basel, Switzerland) · 2017Review
- Surface Plasmon Resonance or Biocompatibility-Key Properties for Determining the Applicability of Noble Metal Nanoparticles.Materials (Basel, Switzerland) · 2017Review
- Label-free biosensing of Salmonella enterica serovars at single-cell level.Journal of nanobiotechnology · 2017Article
- Article
- Diazonium Chemistry for the Bio-Functionalization of Glassy Nanostring Resonator Arrays.Sensors (Basel, Switzerland) · 2015Article
- Aptamer Microarrays-Current Status and Future Prospects.Microarrays (Basel, Switzerland) · 2015Review
- Considerations for designing chemical screening strategies in plant biology.Frontiers in plant science · 2015Review
- Label-free, real-time detection of the dynamic processes of protein degradation using oblique-incidence reflectivity difference method.Applied physics letters · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein microarrays, on which thousands of discrete proteins are printed, provide a valuable platform for functional analysis of the proteome. They have been widely used for biomarker discovery and to study protein-protein interactions. The accomplishments of DNA microarray technology, which had enabled massive parallel studies of gene expression, sparked great interest for the development of protein microarrays to achieve similar success at the protein level. Protein microarray detection techniques are often classified as being label-based and label-free. Most of the microarray applications have employed labelled detection such as fluorescent, chemiluminescent and radioactive labelling. These labelling strategies have synthetic challenges, multiple label issues and may exhibit interference with the binding site. Therefore, development of sensitive, reliable, high-throughput, label-free detection techniques are now attracting significant attention. Label-free detection techniques monitor biomolecular interactions and simplify the bioassays by eliminating the need for secondary reactants. Moreover, they provide quantitative information for the binding kinetics. In this article, we will review several label-free techniques, which offer promising applications for the protein microarrays, and discuss their prospects, merits and challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.