ReviewJournal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews2009
An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology.
Review in Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it, 382 citations in OpenAlex.
- A systematic review of contaminants in donor human milk.Maternal & child nutrition · 2024Pooled it
- An Automated Tool for Predicting Ion-Molecule Reaction Rates in CI-MS: Application to PCDDs and PCDFs.Journal of mass spectrometry : JMS · 2026Article
- Source attribution of polycyclic aromatic hydrocarbons and dioxins in soil and dust following compound climate events in legacy-contaminated environmental justice areas.The Science of the total environment · 2026Article
- A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Review
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
- Article
- Microplastics as environmental modifiers of lung disease.EMBO molecular medicine · 2026Review
- Dioxins and the One Health Paradigm: An Interdisciplinary Challenge in Environmental Toxicology.Toxics · 2025Review
- Multiple Stressors in the Anthropocene: Urban Evolutionary History Modifies Sensitivity to the Toxic Effects of Crude Oil Exposure in Killifish.Evolutionary applications · 2025Article
- Multiple stressors in the Anthropocene: Urban evolutionary history modifies sensitivity to the toxic effects of crude oil exposure in killifish.bioRxiv : the preprint server for biology · 2025Article
- Environmental Contaminants, Iron Deficiency, and Iron-Deficiency Anemia: A Review of the Literature.Scientifica · 2025Review
- The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.Frontiers in endocrinology · 2025Review
- Food contamination and cardiovascular disease: a narrative review.Internal and emergency medicine · 2024Review
- Serum Dioxin Levels in a Subset of Participants of the East Palestine, Ohio Train Derailment Health Tracking Study.Environmental science & technology letters · 2024Article
- The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer.International journal of molecular sciences · 2024Review
- Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study.Archives of craniofacial surgery · 2024Article
- Dioxin(-like)-Related Biological Effects through Integrated Chemical-wide and Metabolome-wide Analyses.Environmental science & technology · 2024Article
- Factors affecting the polychlorinated biphenyl signatures in serum of adults living in a highly polluted area in eastern Slovakia.Frontiers in public health · 2024Article
- Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect.Evolutionary applications · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dioxins and dioxin-like compounds are primary examples of persistent organic pollutants that induce toxicity in both wildlife and humans. Over the past 200 years these compounds have been almost exclusively generated by human activity and have left a string of disasters in the wake of their accidental release. Most recently, the contamination of the Irish pork supply with dioxins resulted in an international recall of all Irish pork products. Epidemiologic data on human and ecological dioxin exposures have revealed a common pattern of biological response among vertebrate species, which is mediated through activation of the Aryl hydrocarbon Receptor (AhR). These AhR-mediated effects include profound consequences on the vertebrate individual exposed in early life with respect to myriad developmental endpoints including neurologic, immunologic, and reproductive parameters. Humans appear to be susceptible to these effects in a manner similar to that of the laboratory and wildlife species, which have demonstrated such outcomes. Furthermore, epidemiologic data suggest that there is little or no margin of exposure for humans with respect to these developmental effects. Given these concerns, prudent public health policy should include the continued reduction of exposures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.