ArticleActa neurochirurgica. Supplement2010
The rationale behind "A Randomized Trial of Unruptured Brain AVMs" (ARUBA).
Article in Acta neurochirurgica. Supplement, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00389181 (A Randomized Trial of Unruptured Brain Arteriovenous Malformations), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of Unruptured Brain Arteriovenous Malformations
Who cites it
7 citing papers in PubMed.
- Unexpected silent infarctions after embolization of cerebral arteriovenous malformations and fistulas. A diffusion-weighted magnetic resonance imaging study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2013Trial
- The ARUBA trial: current status, future hopes.Stroke · 2010Trial
- Review
- Viewpoints on the ARUBA trial.AJNR. American journal of neuroradiology · 2015Article
- Influence of patient age on angioarchitecture of brain arteriovenous malformations.AJNR. American journal of neuroradiology · 2014Article
- Endovascular treatment of ruptured brain AVMs in the acute phase of hemorrhage.AJNR. American journal of neuroradiology · 2012Article
- Partial "targeted" embolisation of brain arteriovenous malformations.European radiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A Randomized Trial of Unruptured Brain AVMs is a multidisciplinary international randomized controlled clinical trial including 800 adult patients with the diagnosis of an unruptured brain AVM. Patients willing to participate are randomly assigned to either best possible invasive therapy (endovascular, neurosurgical, and/or radiation therapy) or medical management without intervention. The study protocol does not modify any routine treatment strategies in either arm. Patients will be followed for a minimum of 5 years and a maximum of 10 years from randomization.The primary outcome measure is the composite endpoint of death from any cause or stroke (clinically symptomatic hemorrhage or infarction confirmed by imaging). The secondary outcome measure is long-term clinical status by Rankin Scale, NIHSS, SF-36, and EuroQol.Patient enrollment was successfully started in 2007. Participating sites currently include multidisciplinary treatment centers in North and South America, Australasia, and Europe (including Australia, Austria, Brazil, Canada, Finland, France, Germany, Italy, Netherlands, Spain, South Korea, Switzerland, UK, and the USA).The trial is sponsored and monitored by the US NIH/NINDS (NCT00389181).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.