Evidence map›Paper›PMID 19953266›Full record

ArticleEuropean journal of pediatrics2010

Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth.

Constantine I Vardavas, Leda Chatzi, Evridiki Patelarou, Estel Plana, Katerina Sarri, Anthony Kafatos, Antonis D Koutis, Manolis Kogevinas

Abstract read
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In one paragraph

Article in European journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Impact of smoking exposure change on infant birth weight among a cohort of women in a prenatal smoking cessation study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
    Trial
  6. Maternal Smoking and Preterm Birth Among Infants With Orofacial Clefts.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  7. Article
  8. Article
  9. Effects of maternal morphine consumption on odontogenesis in rats: A histomorphometric study.Journal of dental research, dental clinics, dental prospects · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Risk of Gestational Diabetes Due to Maternal and Partner Smoking.International journal of environmental research and public health · 2022
    Observational
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Constantine I VardavasDepartment of Social Medicine, University of Crete, PO Box 2208, Heraklion, 71003 Crete, Greece. vardavas@edu.med.uoc.gr
Leda Chatzi
Evridiki Patelarou
Estel Plana
Katerina Sarri
Anthony Kafatos
Antonis D Koutis
Manolis Kogevinas

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal smoking during pregnancy is a significant threat to the fetus. We examined the association between active maternal smoking and smoking cessation during early pregnancy with newborn somatometrics and adverse pregnancy outcomes including preterm delivery, low birth weight, and fetal growth restriction. One thousand four hundred mother-child pairs with extensive questionnaire data were followed up until delivery, within the context of a population-based mother-child cohort study (Rhea study), in Crete, Greece, 2007-2008. Comparing smokers to nonsmokers, the adjusted odds ratio (OR) was 2.8 [95% confidence interval (CI), 1.7, 4.6] for low birth weight and 2.6 (95%CI: 1.6, 4.2) for fetal growth restriction. This corresponded to a 119-g reduction in birth weight, a 0.53-cm reduction in length, and a 0.35-cm reduction in head circumference. Smoking cessation early during pregnancy modified significantly these pregnancy outcomes indicating the necessity for primary smoking prevention.

Indexed as

Smoking CessationAdultEmigrants and ImmigrantsFemaleFetal Growth RetardationGreeceHumansInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeLinear ModelsLogistic ModelsMalePregnancyPregnancy OutcomePremature Birth

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.