ArticleEuropean journal of clinical nutrition2010
Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults.
Article in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies.BMC cardiovascular disorders · 2019Pooled it
- Pooled it
- Vitamin D Status and Mortality: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2019Pooled it
- Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D.American journal of public health · 2014Pooled it
- Vitamin D and subsequent all-age and premature mortality: a systematic review.BMC public health · 2013Pooled it
- Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies.Circulation. Cardiovascular quality and outcomes · 2012Pooled it
- Randomized control trial comparing the effect of cilostazol and aspirin on changes in carotid intima-medial thickness.Heart and vessels · 2019Trial
- A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects.Journal of the American Society of Nephrology : JASN · 2018Trial
- Increased telomerase activity and vitamin D supplementation in overweight African Americans.International journal of obesity (2005) · 2012Trial
- Ten-Year Trends in Serum 25-Hydroxyvitamin D in Slovenia (2014-2023): Laboratory-Based Data from Tested Individuals and COVID-19-Period Changes.Nutrients · 2026Article
- Review
- Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D.Nutrients · 2022Review
- COVID-19 transmission risk factors.Pathogens and global health · 2022Article
- Notable Developments for Vitamin D Amid the COVID-19 Pandemic, but Caution Warranted Overall: A Narrative Review.Nutrients · 2021Review
- Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.Aging clinical and experimental research · 2020Article
- Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.The Journal of nutrition · 2019Article
- Mobilising vitamin D from adipose tissue: The potential impact of exercise.Nutrition bulletin · 2019Review
- The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Review
- The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus.International journal of molecular sciences · 2018Review
- Vitamin D in Vascular Calcification: A Double-Edged Sword?Nutrients · 2018Review
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesVitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures and mortality. Although older adults are at a higher risk of vitamin D deficiency, the relationship of serum 25-hydroxyvitamin D (25(OH)D) with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D levels predicted mortality in older adults. SUBJECTS/
methodsSerum 25(OH)D as well as all-cause and cardiovascular disease mortality were examined in 1006 adults, aged > or =65 years, who participated in the InCHIANTI (Invecchiare in Chianti, Aging in the Chianti Area) study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D levels were measured at the time of enrollment in 1998-1999, and participants were followed up for mortality.
resultsDuring 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due to cardiovascular diseases. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/ml) (to convert to nmol/l, multiply by 2.496), those in the lowest quartile (<10.5 ng/ml) had increased risk of all-cause mortality (Hazard Ratio (H.R.) 2.11, 95% Confidence Interval (95% C.I.): 1.22-3.64, P=0.007) and cardiovascular disease mortality (H.R. 2.64, 95% C.I.: 1.14-4.79, P=0.02), in multivariate Cox proportional hazards models that adjusted for age, sex, education, season, physical activity and other potential confounders.
conclusionsOlder community-dwelling adults with low serum 25(OH)D levels are at higher risk of all-cause and cardiovascular disease mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.