ArticleJournal of immunotherapy (Hagerstown, Md. : 1997)2010
The marginating-pulmonary immune compartment in rats: characteristics of continuous inflammation and activated NK cells.
Article in Journal of immunotherapy (Hagerstown, Md. : 1997), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- Tumor Excision as a Metastatic Russian Roulette: Perioperative Interventions to Improve Long-Term Survival of Cancer Patients.Trends in cancer · 2020Review
- Prevention of liver metastases through perioperative acute CpG-C immune stimulation.Cancer immunology, immunotherapy : CII · 2020Article
- A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress.Journal of neuroimmunology · 2017Article
- Maintaining unperturbed cerebral blood flow is key in the study of brain metastasis and its interactions with stress and inflammatory responses.Brain, behavior, and immunity · 2017Article
- Significantly enhanced lung metastasis and reduced organ NK cell functions in diet-induced obese rats.BMC obesity · 2017Article
- Selective Harvesting of Marginating-hepatic Leukocytes.Journal of visualized experiments : JoVE · 2016Article
- Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects.International journal of cancer · 2016Article
- Selective Harvesting of Marginating-pulmonary Leukocytes.Journal of visualized experiments : JoVE · 2016Article
- Exploiting the critical perioperative period to improve long-term cancer outcomes.Nature reviews. Clinical oncology · 2015Review
- The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity.Brain, behavior, and immunity · 2015Article
- In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins.Brain, behavior, and immunity · 2014Article
- The marginating-pulmonary immune compartment in mice exhibits increased NK cytotoxicity and unique cellular characteristics.Immunologic research · 2014Article
- Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement.Brain, behavior, and immunity · 2013Review
- PGE2 suppresses NK activity in vivo directly and through adrenal hormones: effects that cannot be reflected by ex vivo assessment of NK cytotoxicity.Brain, behavior, and immunity · 2013Article
- A new approach to reducing postsurgical cancer recurrence: perioperative targeting of catecholamines and prostaglandins.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Review
- Continuous stress disrupts immunostimulatory effects of IL-12.Brain, behavior, and immunity · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
A significant role has been indicated for cellular immunity in controlling circulating cancer cells, but most autologous tumor cells seem resistant, in vitro, to natural killer cell (NKC) and cytotoxic T lymphocytes cytotoxicity. Addressing this apparent contradiction, we recently identified a unique leukocyte population, marginating-pulmonary (MP)-leukocytes, which exhibit potent natural killer (NK) cytotoxicity. Here, we characterize the MP-compartment in naive and immunostimulated rats, and assessed its cytotoxicity against "NK-resistant" tumors cells. Animals were treated with poly I-C (3x0.2 mg/kg) or saline, and circulating-leukocytes and MP-leukocytes were collected and analyzed in terms of cellular composition, cellular activation markers, and NK cytotoxicity of leukocytes and purified NKCs. Compared with circulating-leukocytes, MP-leukocytes showed greater proportion of granulocytes, monocytes, NKCs, and large NKCs; higher expression of activation and adhesion markers (CD25, CD11a, CD11b, and NKR-P1, IFN-gamma); and elevated NK cytotoxicity of leukocytes and purified NKCs against several syngeneic and xenogeneic NK-resistant target cells (from both F344 and BDX inbred rats). In immunostimulated animals (treated with poly I-C), but not in naive animals, purified NKCs from the MP-compartment showed markedly superior cytotoxicity, suggesting that poly I-C immunostimulation uniquely affect MP-NKCs, and that in naive animals other MP-leukocytes support NK cytotoxicity. Overall, the results suggest that the MP-compartment is characterized by a continuous activated inflammatory microenvironment uniquely affected by immunostimulation. If similarly potent MP-NKCs exist in patients, then circulating autologous tumor cells that are considered "NK-resistant" could actually be controlled by MP-NKCs. Innate immunity may assume greater role in controlling malignant spread, especially after immunostimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.