Evidence map›Paper›PMID 19952871›Full record

ArticlePharmacogenetics and genomics2010

PharmGKB very important pharmacogene: SLCO1B1.

Connie Oshiro, Lara Mangravite, Teri Klein, Russ Altman

Abstract read
In one paragraph

Article in Pharmacogenetics and genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
    Pooled it
  3. Trial
  4. Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
    Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. International journal of molecular sciences · 2024
    Article
  10. Association ofFrontiers in pharmacology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. [A case of acute liver injury caused by atorvastatin in a patient with SLCO1B1*1b haplotype].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  20. Drug metabolism and disposition: the biological fate of chemicals · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Connie OshiroDepartment of Genetics, Stanford University, CA, USA.
Lara Mangravite
Teri Klein
Russ Altman

Funding

Pharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7M
THE STANFORD PHARMACOGENETICS KNOWLEDGE BASEU01GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2000 to 2009
$24.0M
NHLBI NIH HHS U01 HL069757NHLBI NIH HHS UO1-HL69757NIGMS NIH HHS U01 GM061374NIGMS NIH HHS UO1GM61374
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Databases, GeneticKnowledge BasesPharmacogeneticsAllelesAmino Acid SequenceExonsGene FrequencyGenetic VariationHumansInhibitory Concentration 50KineticsLigandsLiver-Specific Organic Anion Transporter 1Molecular Sequence DataOrganic Anion TransportersPharmaceutical PreparationsLigandsLiver-Specific Organic Anion Transporter 1Organic Anion TransportersPharmaceutical PreparationsSLCO1B1 protein, human

Identifiers

PMID19952871
PMCPMC3086841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.