Trial reportMedicine and science in sports and exercise2010
Effects of different doses of physical activity on C-reactive protein among women.
Trial report in Medicine and science in sports and exercise, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Standard Deviation of Individual Response for VOSports medicine (Auckland, N.Z.) · 2024Pooled it
- The effects of aerobic exercise on cardiometabolic health in postmenopausal females: A systematic review and meta-analysis of randomized controlled trials.Women's health (London, England)Pooled it
- Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis.Heart & lung : the journal of critical carePooled it
- Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women.Scientific reports · 2020Trial
- The effect of high-intensity aerobic interval training on markers of systemic inflammation in sedentary populations.European journal of applied physiology · 2017Trial
- Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA).BMC cancer · 2014Trial
- Effect of diet or diet plus physical activity versus usual care on inflammatory markers in patients with newly diagnosed type 2 diabetes: the Early ACTivity in Diabetes (ACTID) randomized, controlled trial.Journal of the American Heart Association · 2014Trial
- Effect of exercise training modality on C-reactive protein in type 2 diabetes.Medicine and science in sports and exercise · 2012Trial
- Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial.Cancer research · 2012Trial
- Joint Association of Physical Activity and Prognostic Nutritional Index on Survival in US Cancer Survivors: A Study Based on the NHANES Database.Cancer medicine · 2026Article
- Physical activity and exercise within the context of obesity treatment: Enhancing health beyond weight loss.Journal of sport and health science · 2025Review
- The effects of supervised aerobic training on dyslipidaemia among diabetic older patients.BMC endocrine disorders · 2024Observational
- Whole Body Vibration Training Has No Effect on Vascular Endothelial and Inflammatory Markers in Young Healthy Women.Journal of clinical medicine · 2024Article
- The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events.European heart journal open · 2022Review
- Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.Frontiers in cardiovascular medicine · 2021Article
- Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging orAging and disease · 2019Review
- Psychosocial Variables Related to Why Women are Less Active than Men and Related Health Implications.Clinical medicine insights. Women's health · 2016Review
- Recreational Exercise Before and During Pregnancy in Relation to Plasma C-Reactive Protein Concentrations in Pregnant Women.Journal of physical activity & health · 2015Article
- Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents.PloS one · 2015Article
- Biological mechanisms underlying the role of physical fitness in health and resilience.Interface focus · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
unlabelledElevated C-reactive protein (CRP) is associated with an increased risk of cardiovascular disease. Physical activity has been inversely associated with CRP. However, the clinical trials examining the effect of exercise training have produced conflicting results. PURPOSE: The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women.
methodsSedentary, overweight, or obese postmenopausal women with elevated systolic blood pressure (120-160 mm Hg; n = 464) were randomized into one of four groups: a nonexercise control or one of three aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal·kg(-1)·wk(-1) (KKW) for 6 months at a training intensity of 50% of peak VO2.
resultsComplete data for 421 participants were available, and mean (SD) baseline CRP was 5.7 (5.5) mg·L(-1), with no significant differences across groups. Although VO2 increased in a dose-response manner, there were no significant changes in CRP in any of the exercise intervention groups compared with the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP.
conclusionsDespite increasing fitness, 6 months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight.
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