ArticleJournal of occupational and environmental medicine2009
Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination Survey.
Article in Journal of occupational and environmental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 39 citations in OpenAlex.
- Racialized experience, biomarkers of lead exposure, and later-life cognition: a mediation analysis.American journal of epidemiology · 2025Article
- A machine learning analysis of suicidal ideation and suicide attempt among U.S. youth and young adults from multilevel, longitudinal survey data.Frontiers in psychiatry · 2025Article
- Improving prediction of linear regression models by integrating external information from heterogeneous populations: James-Stein estimators.Biometrics · 2024Article
- Do we underestimate risk of cardiovascular mortality due to lead exposure?The Science of the total environment · 2024Article
- Early childhood lead exposure is not reflected in adult bone lead: Results of a sub-cohort of African American women in the Cincinnati lead study.Environmental research · 2023Article
- Biomarkers of maternal lead exposure during pregnancy using micro-spatial child deciduous dentine measurements.Environment international · 2022Article
- Association between Bone Lead Concentration and Aggression in Youth from a Sub-Cohort of the Birth to Twenty Cohort.International journal of environmental research and public health · 2022Article
- The association of bone and blood manganese with motor function in Chinese workers.Neurotoxicology · 2022Article
- Blood DNA methylation biomarkers of cumulative lead exposure in adults.Journal of exposure science & environmental epidemiology · 2021Article
- The Use of Penalized Regression Analysis to Identify County-Level Demographic and Socioeconomic Variables Predictive of Increased COVID-19 Cumulative Case Rates in the State of Georgia.International journal of environmental research and public health · 2020Article
- Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.Environmental health perspectives · 2020Article
- Accounting for established predictors with the multistep elastic net.Statistics in medicine · 2019Article
- The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers.The Science of the total environment · 2019Article
- Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure.International journal of environmental research and public health · 2018Article
- Improving estimation and prediction in linear regression incorporating external information from an established reduced model.Statistics in medicine · 2018Article
- Urinary Lead Concentration Is an Independent Predictor of Cancer Mortality in the U.S. General Population.Frontiers in oncology · 2018Article
- Biased Exposure-Health Effect Estimates from Selection in Cohort Studies: Are Environmental Studies at Particular Risk?Environmental health perspectives · 2015Article
- Unsaturated fatty acids supplementation reduces blood lead level in rats.BioMed research international · 2015Article
- No association between perfluoroalkyl chemicals and hypertension in children.Integrated blood pressure control · 2014Article
- Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study.Environmental health : a global access science source · 2013Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveWe developed prediction models for bone lead using blood lead levels and other standard covariates in a community-based cohort of older men.
methodsParticipants having bone lead levels measured by K X-ray fluorescence were included in the model selection process (n = 825). Predictors of each tibia and patella lead were identified in three quarters of the population and then predicted the bone lead levels in the remaining one quarter and in the Community Lead Study.
resultsEighteen predictors were selected for tibia (blood lead, age, education, occupation, smoking status, pack-years of cigarette, serum levels of phosphorus, uric acid, calcium, creatinine and total and high-density lipoprotein cholesterols, hematocrit, body mass index, systolic and diastolic blood pressure, and diagnoses of cancer and diabetes; R2 = 0.32) and 16 for patella lead (among the predictors included in the tibia model diagnosis of cancer, serum levels of calcium, and total cholesterol were not included in patella lead model, but diagnosis of hypertension was included; R2 = 0.34), respectively. The correlation coefficients between the observed and predicted values were 0.43 to 0.50 for tibia and 0.52 to 0.58 for patella lead in internal and external validation. We applied these predicted bone lead models to the Third National Health and Nutrition Examination Survey (NHANES-III) to examine associations with hypertension and found relatively more significant associations compared with blood lead.
conclusionsThis study suggests that the prediction equations may be used to predict bone lead levels in other community-based cohorts with reasonable accuracy.
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