ArticleAIDS (London, England)2010
Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure.
Article in AIDS (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis.BMC neurology · 2020Pooled it
- Treatment for HIV-associated cryptococcal meningitis.The Cochrane database of systematic reviews · 2018Pooled it
- The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Trial
- Under pressure: a call to increase access to spinal manometers as a critical component of the management of cryptococcal meningitis.AIDS (London, England) · 2026Article
- Review
- The Pain Is in the Brain With the Sugar-Coated Killer.The Journal of infectious diseases · 2025Review
- Article
- Cerebral Perfusion Pressures and Implications on Clinical Outcomes and Medical Management in Cryptococcal Meningitis.Open forum infectious diseases · 2025Article
- Association of arachnoid fossae and endocranial lesions in a historical population from Poland: new diagnostic possibilities.Scientific reports · 2025Article
- Reframing the clinical phenotype and management of cryptococcal meningitis.Practical neurology · 2025Review
- Normal opening pressure lumbar puncture in cryptococcal meningitis complicated by a cerebral venous thrombosis: a case report and literature review.Frontiers in medicine · 2025Article
- Atypical presentation of cryptococcal meningitis in oncology patients: Case Report.Frontiers in medicine · 2025Article
- Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis.ASM case reports · 2025Article
- A multi-arm, parallel, preclinical study investigating the potential benefits of acetazolamide, candesartan, and triciribine in combination with fluconazole for the treatment of cryptococcal meningoencephalitis.European journal of pharmacology · 2023Article
- Author Response: Teaching NeuroImage: Cryptococcal Meningoencephalitis With Cryptococcoma and Gelatinous Pseudocysts.Neurology · 2023Article
- Persistently elevated intracranial pressure in cryptococcal meningitis- 76 therapeutic lumbar punctures.Medical mycology case reports · 2023Article
- Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.PLoS neglected tropical diseases · 2023Article
- Elevated Intracranial Pressure in Cryptococcal Meningoencephalitis: Examining Old, New, and Promising Drug Therapies.Pathogens (Basel, Switzerland) · 2022Review
- Early clinical and microbiological predictors of outcome in hospitalized patients with cryptococcal meningitis.BMC infectious diseases · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveTo investigate the histopathology of the arachnoid granulations in patients with HIV-associated cryptococcal meningitis and correlate the findings with clinical data, in particular cerebrospinal fluid (CSF) opening pressure.
designCase series.
methodsPostmortems were requested on patients dying during initial hospitalization with HIV-associated cryptococcal meningitis.
resultsFive postmortems were performed. Large numbers of cryptococcal cells were seen within the arachnoid granulations. The number of fungal cells correlated with CSF pressure. Inflammatory cell infiltrates and disruption of the normal architecture of the granulations were also observed.
conclusionThe study provides the first direct evidence supporting the obstruction to CSF reabsorption at the level of the arachnoid granulations as the main mechanism underlying the development of raised CSF pressure in HIV-associated cryptococcal meningitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.