ArticleCancer prevention research (Philadelphia, Pa.)2009
Distinct effects of calorie restriction and exercise on mammary gland gene expression in C57BL/6 mice.
Article in Cancer prevention research (Philadelphia, Pa.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Gene expression changes in adipose tissue with diet- and/or exercise-induced weight loss.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- Reduced mitogenicity of sera following weight loss in premenopausal women.Nutrition and cancer · 2011Trial
- Association Between Dairy Production System and Milk Functionality Based on Analysis of miRNAs in Exosomes from Milk.Animals : an open access journal from MDPI · 2024Article
- Recommendations for Healthy Lifestyle for Cancer Prevention and Healthy Aging.Journal of cancer prevention · 2024Article
- Development of a Gold Nanoparticle-Based Sensor for Authentication of Organic Milk Based on Differential Levels of miRNA.Nanomaterials (Basel, Switzerland) · 2024Article
- Variation of miRNA Content in Cow Raw Milk Depending on the Dairy Production System.International journal of molecular sciences · 2022Article
- Cellular and Molecular Players in the Interplay between Adipose Tissue and Breast Cancer.International journal of molecular sciences · 2021Review
- Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice.Cancer research · 2017Article
- Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland.PloS one · 2017Article
- Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology.American journal of physiology. Endocrinology and metabolism · 2016Review
- Gene expression profiling of mammary glands at an early stage of DMBA-induced carcinogenesis in the female Sprague-Dawley rat.European journal of oncology = Giornale europeo di oncologia · 2016Article
- The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.Frontiers in endocrinology · 2015Review
- Calorie restriction and cancer prevention: a mechanistic perspective.Cancer & metabolism · 2013Article
- Weight control and cancer preventive mechanisms: role of insulin growth factor-1-mediated signaling pathways.Experimental biology and medicine (Maywood, N.J.) · 2013Review
- Obesity, energy balance, and cancer: new opportunities for prevention.Cancer prevention research (Philadelphia, Pa.) · 2012Review
- Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1.Cancer medicine · 2012Article
- The role of obesity in cancer survival and recurrence.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Review
- Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Benefits of exercise training on breast cancer progression and inflammation in C3(1)SV40Tag mice.Cytokine · 2011Article
- Differential effects of calorie restriction and exercise on the adipose transcriptome in diet-induced obese mice.Journal of obesity · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Energy balance, including diet, weight, adiposity, and physical activity, is associated with carcinogenesis. Epidemiologic studies indicate that obesity and sedentary and/or active behavior are risk factors for breast cancer in postmenopausal women and survival in both premenopausal and postmenopausal breast cancer patients. Thus, understanding the influence of energy balance modulation on changes in gene expression patterns in the normal mammary gland is important for understanding mechanisms linking energy balance and breast cancer. In a 6-week-long study, female C57BL/6 mice (9-week-old) were randomized into four groups: (a) food consumed ad libitum (AL), (b) AL with access to running wheels (AL+EX), (c) 30% calorie restricted (CR), and (d) 30% CR with access to running wheels (CR+EX). CR mice received 70% of calories but 100% of all other nutrients compared with AL mice. Diet and exercise treatments, individually and combined, had significant effects on body composition and physical activity. Affymetrix oligomicroarrays were used to explore changes in gene expression patterns in total RNA samples from excised whole mammary glands. Contrasting AL versus CR resulted in 425 statistically significant expression changes, whereas AL versus AL+EX resulted in 45 changes, with only 3 changes included among the same genes, indicating that CR and EX differentially influence expression patterns in noncancerous mammary tissue. Differential expression was observed in genes related to breast cancer stem cells, the epithelial-mesenchymal transition, and the growth and survival of breast cancer cells. Thus, CR and EX seem to exert their effects on mammary carcinogenesis through distinct pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.