Trial reportThe Journal of bone and joint surgery. American volume2009
Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study.
Trial report in The Journal of bone and joint surgery. American volume, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Dexamethasone vs. placebo modulation of the perioperative blood immune proteome in patients undergoing total knee arthroplasty.BMC anesthesiology · 2025Trial
- Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings.European journal of applied physiology · 2023Trial
- Trial
- Computer-Assisted Surgery is Associated with Reduced Inflammatory Response in Total Knee Arthroplasty: A Randomized Double-Blinded Control Trial.The archives of bone and joint surgery · 2026Article
- The value of perioperative nutritional risk stratification in the prevention of surgical site infection: precision application from GLIM/PG-SGA to PNI, CONUT, and GNRI.Frontiers in nutrition · 2026Review
- 5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy.Scientific reports · 2025Article
- Article
- Geriatric Surgery Produces a Hypoactive Molecular Phenotype in the Monocyte Immune Gene Transcriptome.Journal of clinical medicine · 2023Article
- Deleterious and Protective Psychosocial and Stress-Related Factors Predict Risk of Spontaneous Preterm Birth.American journal of perinatology · 2023Article
- The Value of Preoperative Systemic Immune-Inflammation Index as a Predictor of Prolonged Hospital Stay in Orthopedic Surgery: A Retrospective Study.International journal of general medicine · 2023Article
- Anterior Cruciate Ligament Reconstruction Surgery: Creating a Permissive Healing Phenotype in Military Personnel and Civilians for Faster Recovery.Military medicine · 2022Article
- Surgical Site Infections and Perioperative Optimization of Host Immunity by Selection of Anesthetics.BioMed research international · 2021Review
- Control of immunity by glucocorticoids in health and disease.Seminars in immunopathology · 2020Review
- Orthopaedic Surgery Elicits a Systemic Anti-Inflammatory Signature.Journal of clinical medicine · 2020Article
- The impact of psychosocial stress and stress management on immune responses in patients with cancer.Cancer · 2019Review
- Stress exposures, neurodevelopment and health measures in the ABCD study.Neurobiology of stress · 2019Article
- Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The short-term stress response - Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity.Frontiers in neuroendocrinology · 2018Review
- Spleen contributes to restraint stress induced changes in blood leukocytes distribution.Scientific reports · 2017Article
- Pediatric Perioperative Stress Responses and Anesthesia.Translational perioperative and pain medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe experience of undergoing surgery is known to induce a short-term, fight-or-flight physiological stress response. As an optimum immune response at the site of surgery would enhance tissue repair, we examined surgical stress-induced immune cell redistribution profiles as predictors, and potential mediators, of short and long-term postoperative recovery. We tested the a priori hypothesis that predefined adaptive immune cell redistribution profiles observed during surgery will predict enhanced postoperative recovery.
methodsThis prospective longitudinal study involved fifty-seven patients undergoing meniscectomy. Knee function was assessed preoperatively and at one, three, eight, sixteen, twenty-four, and forty-eight weeks postoperatively with use of the clinically validated Lysholm scale, which assesses mechanical function, pain, mobility, and the ability to perform daily activities. Surgery-induced immune cell redistribution was measured in the blood at baseline, before surgery, and after surgery.
resultsMixed-model repeated-measures analyses revealed a main effect of immune cell redistribution: patients who showed the predefined "adaptive" lymphocyte and monocyte redistribution profiles during surgery showed enhanced recovery. Interesting differences were also observed between the sexes: women as a group showed less adaptive redistribution and correspondingly showed significantly delayed maximum recovery, requiring forty-eight weeks, compared with men, who required only sixteen weeks. Inter-individual differences in leukocyte redistribution predicted the rate of recovery across both sexes.
conclusionsImmune cell redistribution that is induced by the stress of undergoing surgery can predict (and may partially mediate) postoperative healing and recovery. These findings may provide the basis for identifying patients (either prospectively or during surgery) who are likely to show good as opposed to poor recovery following surgery and for designing interventions that would maximize protective immune responses and enhance the rate and extent of recovery.
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