ArticleGenes & development2009
Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Female- or male-biased offspring generated by targeted distortion of sex chromosome transmission in the mouse.Genetics · 2026Article
- The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026Article
- Acquisition of ampliconic sequences marks a selfish mouse t-haplotype.Nature communications · 2025Article
- Evidence against the role of toll-like receptors 7 and 8 in sex selection in mice, cattle, and humans.iScience · 2025Article
- A fascination with tailless mice: a scientific historical review of studies of the T/t complex.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.PloS one · 2024Article
- Bypassing Mendel's First Law: Transmission Ratio Distortion in Mammals.International journal of molecular sciences · 2023Review
- A meiotic driver alters sperm form and function in house mice: a possible example of spite.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice.Scientific reports · 2022Article
- Soma-to-germline RNA communication.Nature reviews. Genetics · 2022Review
- Sperm bauplan and function and underlying processes of sperm formation and selection.Physiological reviews · 2022Review
- Uncoupling cell division and cytokinesis during germline development in metazoans.Frontiers in cell and developmental biology · 2022Review
- Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.Biological reviews of the Cambridge Philosophical Society · 2021Review
- Mechanisms of meiotic drive in symmetric and asymmetric meiosis.Cellular and molecular life sciences : CMLS · 2021Review
- RAC1 controls progressive movement and competitiveness of mammalian spermatozoa.PLoS genetics · 2021Article
- Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.Molecular biology and evolution · 2020Article
- Within-ejaculate sperm competition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Sex and suicide: The curious case of Toll-like receptors.PLoS biology · 2020Article
- Effects of a male meiotic driver on male and female transcriptomes in the house mouse.Proceedings. Biological sciences · 2019Article
- Differential Sperm Motility Mediates the Sex Ratio Drive Shaping Mouse Sex Chromosome Evolution.Current biology : CB · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The t complex responder (Tcr) encoded by the mouse t haplotype is able to cause phenotypic differences between t and + sperm derived from t/+ males, leading to non-Mendelian inheritance. This capability of Tcr contradicts the concept of phenotypic equivalence proposed for sperm cells, which develop in a syncytium and actively share gene products. By analyzing a Tcr minigene in hemizygous transgenic mice, we show that Tcr gene products are post-meiotically expressed and are retained in the haploid sperm cells. The wild-type allele of Tcr, sperm motility kinase-1 (Smok1), behaves in the same manner, suggesting that Tcr/Smok reveal a common mechanism prone to evolve non-Mendelian inheritance in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.