ArticleLipids in health and disease2009
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Article in Lipids in health and disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- A systematic review of the effect of TNF-alpha antagonists on lipid profiles in patients with rheumatoid arthritis.Clinical rheumatology · 2010Pooled it
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- An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients.Shock (Augusta, Ga.) · 2020Article
- Biothiols and oxidative stress markers and polymorphisms ofOncotarget · 2018Article
- Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.Journal of diabetes investigation · 2018Article
- Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.BMC geriatrics · 2016Article
- Association ofBiomedical reports · 2015Article
- PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity.Journal of lipid research · 2015Article
- The APOB gene polymorphism in the pathogenesis of gallstone disease in pre- and postmenopausal women.Przeglad menopauzalny = Menopause review · 2015Article
- Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol.Journal of lipid research · 2013Article
- Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL.Journal of lipid research · 2013Article
- Association of the rs7395662 SNP in the MADD-FOLH1 and several environmental factors with serum lipid levels in the Mulao and Han populations.International journal of medical sciences · 2013Article
- Dietary cholesterol increases paraoxonase 1 enzyme activity.Journal of lipid research · 2012Article
- Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease.Journal of lipids · 2012Article
- Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.BMC medical genetics · 2011Article
- Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.Stroke · 2011Article
- Large scale association analysis identifies three susceptibility loci for coronary artery disease.PloS one · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGenome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) affecting high density lipoprotein (HDL) or low density lipoprotein (LDL) cholesterol levels; these SNPs may contribute to the genetic basis of vascular diseases.
resultsWe assessed the impact of 34 SNPs at 23 loci on dyslipidemia, key lipid sub-phenotypes, and severe carotid artery disease (CAAD) in a case-control cohort. The effects of these SNPs on HDL and LDL were consistent with those previously reported, and we provide unbiased estimates of the percent variance in HDL (3.9%) and LDL (3.3%) explained by genetic risk scores. We assessed the effects of these SNPs on HDL subfractions, apolipoprotein A-1, LDL buoyancy, apolipoprotein B, and lipoprotein (a) and found that rs646776 predicts apolipoprotein B level while rs2075650 predicts LDL buoyancy. Finally, we tested the role of these SNPs in conferring risk for ultrasonographically documented CAAD stenosis status. We found that two loci, chromosome 1p13.3 near CELSR2 and PSRC1 which contains rs646776, and 19q13.2 near TOMM40 and APOE which contains rs2075650, harbor risk alleles for CAAD.
conclusionOur analysis of 34 SNPs contributing to dyslipidemia at 23 loci suggests that genetic variation in the 1p13.3 region may increase risk of CAAD by increasing LDL particle number, whereas variation in the 19q13.2 region may increase CAAD risk by promoting formation of smaller, denser LDL particles.
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