Evidence map›Paper›PMID 19951355›Full record

ReviewThe FEBS journal2010

Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability.

Jonathan B Chaires

Abstract readReview
In one paragraph

Review in The FEBS journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Rational Polyligand Design for G-Quadruplex Multimer Stabilization.Journal of chemical information and modeling · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Stacking Interactions and Flexibility of Human Telomeric Multimers.Journal of the American Chemical Society · 2023
    Article
  15. Crystal structure of a three-tetrad, parallel, KActa crystallographica. Section F, Structural biology communications · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Emerging accessibility patterns in long telomeric overhangs.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jonathan B ChairesJames Graham Brown Cancer Center, University of Louisville, Kentucky, KY 40202, USA. j.chaires@louisville.edu

Funding

Targeting Nucleic Acids with an Integrated Vitural and Actual ScreenR01GM077422 · NIGMS · UNIVERSITY OF LOUISVILLE · PI CHAIRES, JONATHAN B., TRENT, JOHN O · 2007 to 2020
$3.7M
NIGMS NIH HHS GM077422NIGMS NIH HHS R01 GM077422
6 · The paper itself

Abstract

Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representative thermodynamic and kinetic studies of the folding of human telomeric quadruplex structures. Published thermodynamic data vary widely and are inconsistent; possible reasons for these inconsistencies are discussed. The key issue of whether such folding reactions are a simple two-state process is examined. A tentative energy balance for the folding of telomeric quadruplexes in Na(+) and K(+) solution, and for the conformational transition between these forms is presented.

Indexed as

G-QuadruplexesDNAHumansKineticsModels, MolecularMolecular StructureRNAThermodynamicsDNARNA

Identifiers

PMID19951355
PMCPMC2896281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.