ArticleAlcoholism, clinical and experimental research2010
Ontogeny of the enhanced fetal-ethanol-induced behavioral and neurophysiologic olfactory response to ethanol odor.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies.Frontiers in behavioral neuroscience · 2020Review
- Prenatal Alcohol Exposure as a Case of Involuntary Early Onset of Alcohol Use: Consequences and Proposed Mechanisms From Animal Studies.Frontiers in behavioral neuroscience · 2020Article
- Prenatal alcohol exposure selectively enhances young adult perceived pleasantness of alcohol odors.Physiology & behavior · 2015Article
- Pre-administration of G9a/GLP inhibitor during synaptogenesis prevents postnatal ethanol-induced LTP deficits and neurobehavioral abnormalities in adult mice.Experimental neurology · 2014Article
- Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats.PloS one · 2014Article
- Cortical odor processing in health and disease.Progress in brain research · 2014Review
- Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets.Brain sciences · 2013Article
- Fetal nicotine exposure increases preference for nicotine odor in early postnatal and adolescent, but not adult, rats.PloS one · 2013Article
- Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- Lithium prevents long-term neural and behavioral pathology induced by early alcohol exposure.Neuroscience · 2012Article
- Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice.Molecular brain · 2011Article
- The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats.Alcoholism, clinical and experimental research · 2010Article
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3 authors.
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Abstract
backgroundStudies report a fundamental relationship between chemosensory function and the responsiveness to ethanol, its component orosensory qualities, and its odor as a consequence of fetal ethanol exposure. Regarding odor, fetal exposed rats display enhanced olfactory neural and behavioral responses to ethanol odor at postnatal (P) day 15. Although these consequences are absent in adults (P90), the behavioral effect has been shown to persist into adolescence (P37). Given the developmental timing of these observations, we explored the decay in the response to ethanol odor by examining ages between P37 and young adulthood. Moreover, we sought to determine whether the P15 neurophysiologic effect persists, at least, to P40.
methodsBehavioral and olfactory epithelial (OE) responses of fetal ethanol exposed and control rats were tested at P40, P50, P60, or P70. Whole-body plethysmography was used to quantify each animal's innate behavioral response to ethanol odor. We then mapped the odorant-induced activity across the OE in response to different odorants, including ethanol, using optical recording methods.
resultsRelative to controls, ethanol exposed animals showed an enhanced behavioral response to ethanol odor that, while significant at each age, decreased in magnitude. These results, in conjunction with previous findings, permitted the development of an ontologic odor response model of fetal exposure. The fitted model exemplifies that odor-mediated effects exist at birth, peak in adolescence and then decline, becoming absent by P90. There was no evidence of an effect on the odor response of the OE at any age tested.
conclusionsFetal exposure yields an enhanced behavioral response to ethanol odor that peaks in adolescence and wanes through young adulthood. This occurs absent an enhanced response of the OE. This latter finding suggests that by P40 the OE returns to an ethanol "neutral" status and that central mechanisms, such as ethanol-induced alterations in olfactory bulb circuitry, underlie the enhanced behavioral response. Our study provides a more comprehensive understanding of the ontogeny of fetal-ethanol-induced olfactory functional plasticity and the behavioral response to ethanol odor.
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