ArticleViral immunology2009
Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.
Article in Viral immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of high-throughput datasets reveals cellular responses following hemorrhagic fever virus infection.Viruses · 2011Pooled it
- Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.Journal of molecular biology · 2013Review
- An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity.Virology journal · 2013Article
- The search for animal models for Lassa fever vaccine development.Expert review of vaccines · 2013Review
- A systems biology starter kit for arenaviruses.Viruses · 2012Review
- Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.Journal of virology · 2012Article
- Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.Viral immunology · 2010Article
- Comparative pathogenesis and systems biology for biodefense virus vaccine development.Journal of biomedicine & biotechnology · 2010Review
- Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha.Journal of biomedicine & biotechnology · 2010Article
- Vaccine and adjuvant design for emerging viruses: mutations, deletions, segments and signaling.Bioengineered bugsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-kappaB (NF-kappaB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.