Evidence map›Paper›PMID 19951182›Full record

ArticleViral immunology2009

Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity.

Pritish K Tosh, Richard B Kennedy, Robert A Vierkant, Robert M Jacobson, Gregory A Poland

Open access · greenAbstract read
In one paragraph

Article in Viral immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Correlates of protection induced by vaccination.Clinical and vaccine immunology : CVI · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pritish K ToshMayo Vaccine Research Group, Mayo Clinic , Rochester, Minnesota 55905, USA.
Richard B Kennedy
Robert A Vierkant
Robert M Jacobson
Gregory A Poland
Mayo Clinic · USMayo Clinic in Florida · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
The Immunogenetics of Measles ImmunityR01AI033144 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 1993 to 2022
$8.1M
Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
ROCHESTER EPIDEMIOLOGY PROJECTR01AR030582 · NIAMS · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A · 1986 to 2009
$5.1M
IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSER01AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2001 to 2010
$4.3M
NCRR NIH HHS 1 UL1 RR024150-01NCRR NIH HHS UL1 RR024150NIAID NIH HHS AI 33144NIAID NIH HHS AI 48793NIAID NIH HHS R01 AI033144NIAID NIH HHS R01 AI048793NIAMS NIH HHS R01 AR030582
6 · The paper itself

Abstract

Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

Indexed as

Immunity, CellularAdolescentAntibodies, ViralCells, CulturedChildCytokinesFemaleHumansImmunologic MemoryInterferon-gammaInterleukin-6Leukocytes, MononuclearMaleMeasles-Mumps-Rubella VaccineMinnesotaRubella virusAntibodies, ViralCytokinesIL6 protein, humanInterferon-gammaInterleukin-6Measles-Mumps-Rubella Vaccine

Identifiers

PMID19951182
PMCPMC2831647
OpenAlexW2043544433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.