ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2010
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical uncertainties, health service challenges, and ethical complexities of HIV "test-and-treat": a systematic review.American journal of public health · 2013Pooled it
- Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.The Cochrane database of systematic reviews · 2013Pooled it
- Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review.Antiviral therapy · 2013Pooled it
- Trial
- Acquired Human Immunodeficiency Virus Type 1 Drug Resistance in Rhode Island, USA, 2004-2021.The Journal of infectious diseases · 2024Article
- Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options.AIDS (London, England) · 2020Article
- Self reported adherence to antiretroviral treatment and correlates in Hunan province, the Peoples Republic of China.International journal of nursing sciences · 2018Article
- Article
- Prevalence and predictors of late presentation for HIV care in South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2017Article
- Multimethod Longitudinal HIV Drug Resistance Analysis in Antiretroviral-Therapy-Naive Patients.Journal of clinical microbiology · 2017Article
- Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies.The lancet. HIV · 2017Article
- Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance.Proceedings. Biological sciences · 2017Article
- Improving linkage to HIV care at low-threshold STI/HIV testing sites: An evaluation of the Immediate Staging Pilot Project in Vancouver, British Columbia.Canadian journal of public health = Revue canadienne de sante publique · 2017Article
- National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study.Journal of pharmaceutical and biomedical analysis · 2016Article
- Increased Prevalence of Controlled Viremia and Decreased Rates of HIV Drug Resistance Among HIV-Positive People Who Use Illicit Drugs During a Community-wide Treatment-as-Prevention Initiative.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Illness Representations of HIV Positive Patients Are Associated with Virologic Success.Frontiers in psychology · 2016Article
- Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men.BMC infectious diseases · 2015Article
- HIV drug resistance testing by high-multiplex "wide" sequencing on the MiSeq instrument.Antimicrobial agents and chemotherapy · 2015Article
- Cohort Profile: HAART Observational Medical Evaluation and Research (HOMER) cohort.International journal of epidemiology · 2015Observational
4 more citing papers are in PubMed but not listed here.
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Abstract
backgroundThere have been limited studies evaluating temporal changes in the incidence of detection of drug resistance among human immunodeficiency virus type 1 (HIV-1) isolates and concomitant changes in plasma HIV load for treated individuals in a population-wide setting.
methodsLongitudinal plasma viral load and genotypic resistance data were obtained from patients receiving antiretroviral therapy from the British Columbia Drug Treatment Program from July 1996 through December 2008. A total of 24,652 resistance tests were available from 5422 individuals. The incidence of successful plasma viral load suppression and of resistance to each of 3 antiretroviral categories (nucleoside/nucleotide reverse-transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors) was calculated for the population receiving therapy.
resultsThere has been a drastic decrease in the incidence of new cases of HIV-1 drug resistance in individuals followed during 1996-2008. In 1997, the incidence rate of any newly detected resistance was 1.73 cases per 100 person-months of therapy, and by 2008, the incidence rate had decreased >12-fold, to 0.13 cases per 100 person-months of therapy. This decrease in the incidence of resistance has occurred at an exponential rate, with half-times on the order of 2-3 years. Concomitantly, the proportion of individuals with plasma viral load suppression has increased linearly over time (from 64.7% with HIV RNA levels <50 copies/mL in 2000 to 87.0% in 2008; R2=0.97; P<.001).
conclusionsOur results suggest an increasing effectiveness of highly active antiretroviral therapy at the populational level. The vast majority of treated patients in British Columbia now have either suppressed plasma viral load or drug-susceptible HIV-1, according to their most recent test results.
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