ArticleAntioxidants & redox signaling2010
PAMM: a redox regulatory protein that modulates osteoclast differentiation.
Article in Antioxidants & redox signaling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- The miR4261/PAMM axis in multiple myeloma promotes bone resorption.Scientific reports · 2026Article
- Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggeredInternational journal of biological sciences · 2026Article
- Persistent myeloid cell reprogramming despite miltefosine treatment in leishmania-infected macaques.iScience · 2025Article
- TransST: transfer learning embedded spatial factor modeling of spatial transcriptomics data.BMC bioinformatics · 2025Article
- Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice.Nature communications · 2025Article
- Genome-wide copy number variation detection in a large cohort of diverse horse breeds by whole-genome sequencing.Frontiers in veterinary science · 2023Article
- Article
- Identification of four differentially expressed genes associated with acute and chronic spinal cord injury based on bioinformatics data.Neural regeneration research · 2021Article
- Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.Redox biology · 2020Article
- Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI.Journal of translational medicine · 2020Article
- Cinnamtannin B-1 Prevents Ovariectomy-Induced OsteoporosisFrontiers in pharmacology · 2020Article
- miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A.Redox biology · 2019Article
- Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Graphene Oxide-Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y).International journal of molecular sciences · 2017Article
- Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling.Scientific reports · 2016Article
- Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling.The Biochemical journal · 2015Article
- A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.Redox biology · 2015Article
- Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes.Molecular metabolism · 2015Article
- A novel candidate region for genetic adaptation to high altitude in Andean populations.PloS one · 2015Article
- Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes.Antioxidants & redox signaling · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The central role of reactive oxygen species (ROS) in osteoclast differentiation and in bone homeostasis prompted us to characterize the redox regulatory system of osteoclasts. In this report, we describe the expression and functional characterization of PAMM, a CXXC motif-containing peroxiredoxin 2-like protein expressed in bone marrow monocytes on stimulation with M-CSF and RANKL. Expression of wild-type (but not C to G mutants of the CXXC domain) PAMM in HEK293 cells results in an increased GSH/GSSG ratio, indicating a shift toward a more reduced environment. Expression of PAMM in RAW264.7 monocytes protected cells from hydrogen peroxide-induced oxidative stress, indicating that PAMM regulates cellular redox status. RANKL stimulation of RAW 264.7 cells caused a decrease in the GSH/GSSG ratio (reflecting a complementary increase in ROS). In addition, RANKL-induced osteoclast formation requires phosphorylation and translocation of NF-kappaB and c-Jun. In stably transfected RAW 264.7 cells, PAMM overexpression prevented the reduction of GSH/GSSG induced by RANKL. Concurrently, PAMM expression completely abolished RANKL-induced p100 NF-kappaB and c-Jun activation, as well as osteoclast formation. We conclude that PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.