Evidence map›Paper›PMID 19950946›Full record

ArticleJournal of the American Chemical Society2009

A turn-on fluorescent sensor for detecting nickel in living cells.

Sheel C Dodani, Qiwen He, Christopher J Chang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Localizable Fluorescent Metal Ion Indicators With Tunable Colors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Two-Dimensional Graphitic Carbon Nitride (g-CJournal of functional biomaterials · 2022
    Review
  12. Direct Detection of the Labile Nickel Pool inJournal of the American Chemical Society · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. BODIPY Fluorophores for Membrane Potential Imaging.Journal of the American Chemical Society · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sheel C DodaniDepartment of Chemistry and the Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.
Qiwen He
Christopher J Chang

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Howard Hughes Medical InstituteNIGMS NIH HHS GM 79465NIGMS NIH HHS R01 GM079465
6 · The paper itself

Abstract

We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni(2+) in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni(2+) over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni(2+) levels in a respiratory cell model.

Indexed as

AcetatesBoron CompoundsCell Culture TechniquesCell Line, TumorCell SurvivalFluorescent DyesHumansMicroscopy, ConfocalMolecular StructureNickelSpectrometry, Fluorescence4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAcetatesBoron CompoundsFluorescent DyesNickel

Identifiers

PMID19950946
PMCPMC2810492

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.