ReviewInternal and emergency medicine2010
Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications.
Review in Internal and emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes.The Journal of biological chemistry · 2012Trial
- CH50 as a Clinically Useful Biomarker of Disease Activity and Antihistamine Resistance in Chronic Spontaneous Urticaria: An Observational Ambispective Single-Center Study.International journal of dermatology · 2026Observational
- Integrated Transcriptomic Analysis Unveils Hub Genes and Immune Dysregulation in Chronic Spontaneous Urticaria Pathogenesis.Journal of inflammation research · 2026Article
- Acute mountain sickness prediction: a concerto of multidimensional phenotypic data and machine learning strategies in the framework of predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Role of Inflammatory Cytokines in Rheumatoid Arthritis and Development of Atherosclerosis: A Review.Medicina (Kaunas, Lithuania) · 2023Review
- Genetic Variants Leading to Urticaria and Angioedema and Associated Biomarkers.The journal of allergy and clinical immunology. In practice · 2023Article
- Chronic spontaneous urticaria: a low-grade disseminated intravascular coagulation only partially reversed by Omalizumab.Clinical and experimental medicine · 2023Article
- Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease.Journal of clinical medicine · 2022Review
- Biomarkers of disease activity in patients with chronic spontaneous urticaria.Postepy dermatologii i alergologii · 2021Article
- Chronic Urticaria: Advances in Understanding of the Disease and Clinical Management.Clinical reviews in allergy & immunology · 2021Review
- A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis.Advances in experimental medicine and biology · 2021Article
- Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Review
- Coagulation and Skin Autoimmunity.Frontiers in immunology · 2019Review
- Article
- Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria.Allergy, asthma & immunology research · 2015Article
- Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.BioMed research international · 2015Article
- Asymptomatic acute myocardial injury during allergic reaction to hymenoptera venom.Internal and emergency medicine · 2012Article
- Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases.Clinical and experimental immunology · 2011Article
- Angioedema due to C1 inhibitor deficiency in 2010.Internal and emergency medicine · 2010Review
- Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications. [corrected]Internal and emergency medicine · 2010Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic urticaria (CU) is a skin disorder characterized by the recurrent eruption of short-lived wheals accompanied by redness and itching for at least 6 weeks. The wheals can be associated with angioedema. CU is considered an autoimmune disease in about 50% of cases with the presence of circulating histamine releasing autoantibodies mainly directed against the high affinity IgE receptor FcepsilonRI on mast cells and basophils or against IgE. In several CU cases regarded as idiopathic; the actual pathophysiological mechanisms are still unknown. Some patients with CU do not respond to antihistamines and require the use of systemic steroids or cyclosporin, which are, however, not always effective. In CU, several investigators have demonstrated the activation of coagulation that is due to the involvement of eosinophils and a tissue factor pathway with generation of thrombin potentially contributing to an increased vascular permeability. CU patients often present with elevation of coagulation and fibrinolysis markers, such as prothrombin fragment F1+2 and D: -dimer, which correlate with the disease severity. Preliminary data indicate that anticoagulant treatment with heparin and warfarin may be effective in reducing the symptoms of this disorder. Taken together, all these findings provide the rationale for proposing clinical trials on the use of anticoagulant drugs as adjuvant treatment in CU patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.