ArticleClinical and experimental medicine2010
DNA methylation and not allelic variation regulates STAT6 expression in human T cells.
Article in Clinical and experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.Cell death & disease · 2026Article
- Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.Clinical immunology (Orlando, Fla.) · 2018Article
- Changes in DNA Methylation from Age 18 to Pregnancy in Type 1, 2, and 17 T Helper and Regulatory T-Cells Pathway Genes.International journal of molecular sciences · 2018Article
- Article
- Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects.Respiratory research · 2015Article
- Article
- Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation.Clinical epigenetics · 2014Article
- Epigenomics and allergic disease.Epigenomics · 2013Review
- Epigenetics in immune-mediated pulmonary diseases.Clinical reviews in allergy & immunology · 2013Review
- Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness.American journal of respiratory cell and molecular biology · 2013Article
- Signal transducer and activator of transcription 6 polymorphism and asthma risk: a meta-analysis.International journal of clinical and experimental medicine · 2013Article
- Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression.PloS one · 2013Article
- Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children.Clinical epigenetics · 2012Article
- Early life precursors, epigenetics, and the development of food allergy.Seminars in immunopathology · 2012Review
- Epigenetics, asthma, and allergic diseases: a review of the latest advancements.Current allergy and asthma reports · 2012Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, Th2 cell development and IgE secretion; therefore, they primarily contain the Th1 phenotype. However, the mechanism responsible for regulation of STAT6 expression transcriptionally and post-transcriptionally has yet to be elucidated. Here, we characterized the human STAT6 promoter gene and found that the transcriptional regulatory elements CCAAT and ATF were important for the STAT6 promoter activity. Direct sequencing analysis revealed that the 13 GT repeat allelic variation in noncoding exon 1 of the STAT6 gene appeared more frequently in 91 patients with asthma or rheumatoid arthritis than the 15 GT repeat variation, which is the dominant phenotype in healthy controls. However, it appears that this allelic variation did not affect the STAT6 transcriptional activity. Interestingly, treatment with a DNA methyltransferase inhibitor markedly increased the expression of STAT6 mRNA and protein in human primary T cells. In contrast, IFN-gamma treatment significantly repressed the STAT6 transcriptional activity. Therefore, the present study provides insight into the molecular basis of STAT6 expression, and in particular, demonstrates that STAT6 expression is associated with DNA hypermethylation rather than promoter polymorphisms or allelic variations.
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