ArticleDevelopment genes and evolution2009
Involvement of Hox genes in shell morphogenesis in the encapsulated development of a top shell gastropod (Gibbula varia L.).
Article in Development genes and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 60 citations in OpenAlex.
- A microRNA Catalogue for Red Abalone Larvae Reveals Developmental and Acidification-Associated Abundance Patterns.Marine biotechnology (New York, N.Y.) · 2026Article
- Evolution of Duplicated Hox Gene Clusters in Land Snails and Slugs.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Molluscan Shells, Spicules, and Gladii Are Evolutionarily Deeply Conserved.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Cell type and gene regulatory network approaches in the evolution of spiralian biomineralisation.Briefings in functional genomics · 2023Review
- Octopod Hox genes and cephalopod plesiomorphies.Scientific reports · 2023Article
- Comparative Single-Cell Transcriptomics Reveals Novel Genes Involved in Bivalve Embryonic Shell Formation and Questions Ontogenetic Homology of Molluscan Shell Types.Frontiers in cell and developmental biology · 2022Article
- Non-collinear Hox gene expression in bivalves and the evolution of morphological novelties in mollusks.Scientific reports · 2021Article
- Mantle Modularity Underlies the Plasticity of the Molluscan Shell: Supporting Data FromFrontiers in genetics · 2021Article
- Early shell field morphogenesis of a patellogastropod mollusk predominantly relies on cell movement and F-actin dynamics.BMC developmental biology · 2020Article
- Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hox gene expression during development of the phoronidEvoDevo · 2020Article
- Learning from beautiful monsters: phylogenetic and morphogenetic implications of left-right asymmetry in ammonoid shells.BMC evolutionary biology · 2019Article
- Clam Genome Sequence Clarifies the Molecular Basis of Its Benthic Adaptation and Extraordinary Shell Color Diversity.iScience · 2019Article
- Growth and morphogenesis of the gastropod shell.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The evolution of molluscs.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Article
- Staggered Hox expression is more widespread among molluscs than previously appreciated.Proceedings. Biological sciences · 2018Article
- Possible co-option ofBiology letters · 2017Article
- Brain regionalization genes are co-opted into shell field patterning in Mollusca.Scientific reports · 2017Article
- A SoxC gene related to larval shell development and co-expression analysis of different shell formation genes in early larvae of oyster.Development genes and evolution · 2017Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Regulatory gene expression during the patterning of molluscan shells has only recently drawn the attention of scientists. We show that several Hox genes are expressed in association with the shell gland and the mantle in the marine vetigastropod Gibbula varia (L.). The expression of Gva-Hox1, Gva-Post2, and Gva-Post1 is initially detected in the trochophore larval stage in the area of the shell field during formation of embryonic shell. Later, during development, these genes are expressed in the mantle demonstrating their continuous role in larval shell formation and differentiation of mantle edge that secretes the adult shell. Gva-Hox4 is expressed only late during the development of the veliger-like larva and may also be involved in the adult shell morphogenesis. Additionally, this gene also seems to be associated with secretion of another extracellular structure, the operculum. Our data provide further support for association of Hox genes with shell formation which suggest that the molecular mechanisms underlying shell synthesis may consist of numerous conserved pattern-formation genes. In cephalopods, the only other molluscan class in which Hox gene expression has been studied, no involvement of Hox genes in shell formation has been reported. Thus, our results suggest that Hox genes are coopted to various functions in molluscs.
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