Evidence map›Paper›PMID 19949802›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010

Expression of neuronal antigens and related ventral and dorsal proteins in the normal spinal cord and a surgically induced open neural tube defect of the spine in chick embryos: an immunohistochemical study.

Do-Hun Lee, Ji Hoon Phi, You-Nam Chung, Yun-Jin Lee, Seung-Ki Kim, Byung-Kyu Cho, Dong Won Kim, Moon-Sik Park, Kyu-Chang Wang

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Experimental models of spinal open neural tube defect and Chiari type II malformation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Do-Hun LeeDivision of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea.
Ji Hoon Phi
You-Nam Chung
Yun-Jin Lee
Seung-Ki Kim
Byung-Kyu Cho
Dong Won Kim
Moon-Sik Park
Kyu-Chang Wang
Seoul National University Children's Hospital · KRKeimyung University · KRNew Generation University College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aims of this study were to elucidate the processes of neuronal differentiation and ventrodorsal patterning in the spinal cord of the chick embryo from embryonic day (E) 3 to E17 and to study the effect of a prenatal spinal open neural tube defect (ONTD) on these processes.

methodExpression patterns of neuronal antigens (neuronal nuclear antigen, neurofilament-associated protein (NAP), and synaptophysin) and related ventral markers [sonic hedgehog, paired box gene (PAX)6, and islet-1], and dorsal markers (bone morphogenetic protein, Notch homolog 1, and PAX7) were investigated in the normal spinal cord and in a surgically induced spinal ONTD in chick embryos. Four normal and ONTD chick embryos were used for each antigen group. RESULT &

conclusionThere were no differences in the expression of neuronal and ventrodorsal markers between the control and ONTD groups. NAP and synaptophysin were useful for identifying dorsal structures in the distorted anatomy of the ONTD chicks.

Indexed as

Gene Expression ProfilingAnimalsBody PatterningChick EmbryoGene ExpressionImmunohistochemistryNerve Tissue ProteinsNeural Tube DefectsSpinal CordNerve Tissue Proteins

Identifiers

PMID19949802
OpenAlexW2036638984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.