ArticleThe Korean journal of internal medicine2009
Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia.
Article in The Korean journal of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Uncovering hidden HCV infections in adults over 55: reflex testing and insights for opportunistic screening in a tertiary care setting.Archives of public health = Archives belges de sante publique · 2026Article
- The usefulness of anti-HCV signal to cut-off ratio in predicting hepatitis C viremia and the effect of genotype differences on signal to cut-off ratio.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Chronic viral hepatitis accelerates lung function decline in smokers.Clinical and experimental medicine · 2023Article
- Article
- The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection.The Korean journal of internal medicine · 2023Article
- Micro-Elimination of Hepatitis C among Patients with Kidney Disease by Using Electronic Reminder System-A Hospital-Based Experience.Journal of clinical medicine · 2022Article
- The role of a two-assay serological testing strategy for anti-HCV screening in low-prevalence populations.Scientific reports · 2021Article
- Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.PloS one · 2021Article
- Prevalence and characteristics of hepatitis C virus infection in Shenyang City, Northeast China, and prediction of HCV RNA positivity according to serum anti-HCV level: retrospective review of hospital data.Virology journal · 2020Article
- Association of hepatitis status with surgical outcomes in patients with dual hepatitis B and C related hepatocellular carcinoma.Infectious agents and cancer · 2017Article
- The Usefulness of Anti-HCV Signal to Cut-off Ratio in Predicting Viremia in Anti-HCV in Patients With Hepatitis C Virus Infection.Jundishapur journal of microbiology · 2015Article
- Clinical application evaluation of two fourth-generation human immunodeficiency virus (HIV) screening assays in West China Hospital.Journal of clinical laboratory analysis · 2015Article
- Comparison between screening and confirmatory serological assays in blood donors in a region of South Italy.Journal of clinical laboratory analysis · 2014Article
- Infection frequency of hepatitis C virus and IL28B haplotypes in Papua New Guinea, Fiji, and Kiribati.PloS one · 2013Article
- Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances.World journal of hepatology · 2012Article
- Comparison of serial Hepatitis C virus detection in samples submitted through serology for reflex confirmation versus samples directly submitted for quantitation.Journal of clinical microbiology · 2011Article
- Establishing a sample-to cut-off ratio for lab-diagnosis of hepatitis C virus in Indian context.Asian journal of transfusion scienceArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsHepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) for predicting HCV RNA results.
methodsPatients on whom a qualitative HCV RNA test was performed due to a positive anti-HCV enzyme immunoassay were enrolled. Patients were divided into viremia and no-viremia groups according to HCV RNA results. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO for a diagnosis of viremia.
resultsIn total, 487 patients were enrolled. HCV RNA was positive in 301 subjects (61.8%). Age, serum ALT level, and anti-HCV S/CO ratio were significantly different between the viremia and no-viremia groups. By ROC curve analysis, anti-HCV S/CO ratio (area, 0.989; 95% confidence interval, 0.981 to 0.998) accurately predicted the presence of viremia, with a cutoff value of 10.9 (sensitivity, 94.4%; specificity, 97.3%).
conclusionsAnti-HCV S/CO ratio was found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be used to determine whether a quantitative or qualitative HCV RNA test should be used to confirm HCV viremia in patients with a positive anti-HCV by the following criteria: if the anti-HCV S/CO ratio is <10.9, a qualitative HCV RNA test can be used, and if the anti-HCV S/CO ratio is >or=10.9 a quantitative HCV RNA test can be performed.
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