ArticleCurrent neuropharmacology2009
The serotonergic system: its role in pathogenesis and early developmental treatment of autism.
Article in Current neuropharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials.Open veterinary journal · 2024Pooled it
- Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism.Cerebral cortex (New York, N.Y. : 1991) · 2015Trial
- Inverse fluoxetine effects on inhibitory brain activation in non-comorbid boys with ADHD and with ASD.Psychopharmacology · 2015Trial
- Switching brain serotonin with oxytocin.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuromodulation of Swarming Behavior inbioRxiv : the preprint server for biology · 2025Article
- Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism.Scientific reports · 2025Article
- Tryptophan hydroxylase 2 deficiency alters autism-related behavioural phenotypes in rats.Scientific reports · 2025Article
- Serotonergic Dynamics in Autism Spectrum Disorder: Unraveling the Intricate Connection.CNS & neurological disorders drug targets · 2025Review
- The 'PSILAUT' protocol: an experimental medicine study of autistic differences in the function of brain serotonin targets of psilocybin.BMC psychiatry · 2024Article
- Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions.Environmental research · 2023Article
- Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex.International journal of molecular sciences · 2021Article
- Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder.Scientific reports · 2020Article
- Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.Molecular autism · 2020Article
- Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder.Frontiers in genetics · 2020Article
- Association of human serotonin receptor 4 promoter methylation with autism spectrum disorder.Medicine · 2020Observational
- Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats.Scientific reports · 2019Article
- Effects of Acute Tryptophan Depletion on Repetitive Behavior in Laying Hens.Frontiers in veterinary science · 2019Article
- Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a severe childhood disorder already presenting in the first 3 years of life and, therefore, strongly correlated with neurodevelopmental alterations in prenatal, as well as postnatal period. Neurotransmitters hold a pivotal role in development by providing the stimulation needed for synapses and neuronal networks to be formed during the critical period of neuroplasticity. Aberrations of the serotonergic system modify key processes in the developing brain and are strongly implicated in the pathophysiology of developmental disorders. Evidence for the role of serotonin in autism emerges from neuropathological, imaging and genetic studies. Due to its developmental arrest, autism requires early intervention that would, among others, target the disrupted serotonergic system and utilize brain plasticity to elicit clinically important brain changes in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.