ArticleFrontiers in behavioral neuroscience2009
Local hippocampal methamphetamine-induced reinforcement.
Article in Frontiers in behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalingsJournal of ginseng research · 2022Article
- MeBib Suppressed Methamphetamine Self-Administration Response via Inhibition of BDNF/ERK/CREB Signal Pathway in the Hippocampus.Biomolecules & therapeutics · 2020Article
- The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line.Neurotoxicity research · 2020Article
- Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats.The journal of physiological sciences : JPS · 2019Article
- Voluntary inhalation of methamphetamine: a novel strategy for studying intake non-invasively.Psychopharmacology · 2017Article
- Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Caught in the Net: Perineuronal Nets and Addiction.Neural plasticity · 2016Review
- Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.Scientific reports · 2015Article
- Hippocampal volume reduction in female but not male recent abstinent methamphetamine users.Behavioural brain research · 2015Article
- Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine.Journal of neurochemistry · 2015Article
- The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats.Basic and clinical neuroscience · 2015Article
- Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Emotions and motivated behavior converge on an amygdala-like structure in the zebrafish.The European journal of neuroscience · 2014Article
- Cocaine seeking and taking: role of hippocampal dopamine D1-like receptors.The international journal of neuropsychopharmacology · 2014Article
- Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.Synapse (New York, N.Y.) · 2013Article
- Prior methamphetamine self-administration attenuates serotonergic deficits induced by subsequent high-dose methamphetamine administrations.Drug and alcohol dependence · 2012Article
- The Hepatocyte Growth Factor/c-Met Antagonist, Divalinal-Angiotensin IV, Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats.Brain sciences · 2012Article
- CNS dopamine transmission mediated by noradrenergic innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Brain Circuits of Methamphetamine Place Reinforcement Learning: The Role of the Hippocampus-VTA Loop.Brain and behavior · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drug abuse and addiction are major problems in the United States. In particular methamphetamine (METH) use has increased dramatically. A greater understanding of how METH acts on the brain to induce addiction may lead to better therapeutic targets for this problem. The hippocampus is recognized as an important structure in learning and memory, but is not typically associated with drug reinforcement or reward processes. Here, the focus is on the hippocampus which has been largely ignored in the addiction literature as compared to the nucleus accumbens (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC). The results show that METH administered unilaterally via a microdialysis probe to rats' right dorsal hippocampus will induce drug-seeking (place preference) and drug-taking (lever-pressing) behavior. Furthermore, both of these responses are dependent on local dopamine (DA) receptor activation, as they are impaired by a selective D(1)/D(5) receptor antagonist. The results suggest that the hippocampus is part of the brain's reward circuit that underlies addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.