ArticleFrontiers in cellular neuroscience2009
Implications of functional anatomy on information processing in the deep cerebellar nuclei.
Article in Frontiers in cellular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.Neuroscience bulletin · 2026Article
- Perineuronal nets in cerebellar nuclei neurons orchestrate social behaviour via regulation of neuronal activity in circuits innervated by the cerebellum.Translational psychiatry · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model.Science advances · 2025Article
- Glycosaminoglycan sugar side chains on perineuronal nets in the fastigial nucleus regulate motor skills.iScience · 2025Article
- Mutation inFrontiers in neuroscience · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
- Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy.Brain pathology (Zurich, Switzerland) · 2023Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.bioRxiv : the preprint server for biology · 2023Article
- Article
- Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons.Frontiers in systems neuroscience · 2023Article
- Gating by Memory: a Theory of Learning in the Cerebellum.Cerebellum (London, England) · 2022Article
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases.Scientific reports · 2022Article
- A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue.Frontiers in molecular neuroscience · 2022Article
- Structure, Function, and Genetics of the Cerebellum in Autism.Journal of psychiatry and brain science · 2022Article
- Cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor.Heliyon · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum has been implicated as a major player in producing temporal acuity. Theories of cerebellar timing typically emphasize the role of the cerebellar cortex while overlooking the role of the deep cerebellar nuclei (DCN) that provide the sole output of the cerebellum. Here we review anatomical and electrophysiological studies to shed light on the DCN's ability to support temporal pattern generation in the cerebellum. Specifically, we examine data on the structure of the DCN, the biophysical properties of DCN neurons and properties of the afferent systems to evaluate their contribution to DCN firing patterns. In addition, we manipulate one of the afferent structures, the inferior olive (IO), using systemic harmaline injection to test for a network effect on activity of single DCN neurons in freely moving animals. Harmaline induces a rhythmic firing pattern of short bursts on a quiescent background at about 8 Hz. Other neurons become quiescent for long periods (seconds to minutes). The observed patterns indicate that the major effect harmaline exerts on the DCN is carried indirectly by the inhibitory Purkinje cells (PCs) activated by the IO, rather than by direct olivary excitation. Moreover, we suggest that the DCN response profile is determined primarily by the number of concurrently active PCs, their firing rate and the level of synchrony occurring in their transitions between continuous firing and quiescence. We argue that DCN neurons faithfully transfer temporal patterns resulting from strong correlations in PCs state transitions, while largely ignoring the timing of simple spikes from individual PCs. Future research should aim at quantifying the contribution of PC state transitions to DCN activity, and the interplay between the different afferent systems that drive DCN activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.