ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- A poxvirus model reveals general correlates of antigen presentation and immunogenicity for viral CD8Science advances · 2025Article
- A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.Molecular therapy. Methods & clinical development · 2023Article
- Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Immunoinformatics: Predicting Peptide-MHC Binding.Annual review of biomedical data science · 2020Article
- Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.PloS one · 2018Article
- Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection.Cell reports · 2017Article
- Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Discovering protective CD8 T cell epitopes--no single immunologic property predicts it!Current opinion in immunology · 2015Review
- T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Immunity · 2015Article
- Both positive and negative effects on immune responses by expression of a second class II MHC molecule.Molecular immunology · 2014Article
- A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice.European journal of immunology · 2014Article
- Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8⁺ T cells.Journal of virology · 2013Article
- Discovering naturally processed antigenic determinants that confer protective T cell immunity.The Journal of clinical investigation · 2013Article
- Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.Cell host & microbe · 2013Article
- Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Immunodomination during peripheral vaccinia virus infection.PLoS pathogens · 2013Article
- Humoral immunity to smallpox vaccines and monkeypox virus challenge: proteomic assessment and clinical correlations.Journal of virology · 2013Article
- Kinetics of antigen expression and epitope presentation during virus infection.PLoS pathogens · 2013Article
- Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host.Immunology · 2012Article
- The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude.Journal of immunology (Baltimore, Md. : 1950) · 2012Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies of CD8(+) T cell immunodominance after primary virus infection of F(1) mice compared with their inbred parents have generally concluded that no dramatic changes occur. In this study, we revisit this issue using vaccinia virus (VACV), which has a large genome, a recently defined immunodominance hierarchy in mice, and is a candidate vector for vaccines. We found that immunogenicity of VACV peptides defined using inbred mice was highly variable in F(1) progeny: some peptides were equally immunogenic in F(1) and inbred, whereas others elicited responses that were reduced by >90% in F(1) mice. Furthermore, the dominance of a peptide in the relevant inbred parent did not predict whether it would be poorly immunogenic in F(1) mice. This result held using F(1) hybrids of MHC-congenic mice, suggesting that MHC differences alone were responsible. It was also extended to foreign epitopes expressed by an rVACV vaccine. F(1) mice were less able to mount responses to the poorly immunogenic peptides when used as a sole immunogen, ruling out immunodomination. In addition, conserved TCR Vbeta usage between inbred and F(1) mice did not always correlate with strong responses in F(1) mice. However, direct estimation of naive precursor numbers showed that these were reduced in F(1) compared with inbred mice for specificities that were poorly immunogenic in the hybrids. These data have implications for our understanding of the extent to which MHC diversity alters the range of epitopes that are immunogenic in outbred populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.