ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- The peculiar features, diversity and impact of citrulline-reactive autoantibodies.Nature reviews. Rheumatology · 2024Review
- Cystic fibrosis autoantibody signatures associate withFrontiers in immunology · 2023Article
- Redox-Mediated Carbamylation As a Hapten Model Applied to the Origin of Antibodies to Modified Proteins in Rheumatoid Arthritis.Antioxidants & redox signaling · 2022Review
- Molecular Dynamics Study of Citrullinated Proteins Associated with the Development of Rheumatoid Arthritis.Proteomes · 2022Article
- A fructosylated peptide derived from a collagen II T cell epitope for long-term treatment of arthritis (FIA-CIA) in mice.Scientific reports · 2021Article
- Location, location, location: how the tissue microenvironment affects inflammation in RA.Nature reviews. Rheumatology · 2021Review
- Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis.RMD open · 2021Review
- Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis.ACS chemical biology · 2019Article
- Characterizing the autoreactive B cell transcriptome.Nature reviews. Rheumatology · 2019Article
- Behçet's Syndrome as a Model of Thrombo-Inflammation: The Role of Neutrophils.Frontiers in immunology · 2019Review
- Elucidating the endogenous synovial fluid proteome and peptidome of inflammatory arthritis using label-free mass spectrometry.Clinical proteomics · 2019Article
- Hazelnut-enriched chocolate improves flow-mediated artery dilatation via inhibition of oxidative stress.Internal and emergency medicine · 2018Article
- Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis.Arthritis research & therapy · 2018Article
- A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis.Current opinion in rheumatology · 2017Review
- The Infectious Basis of ACPA-Positive Rheumatoid Arthritis.Frontiers in microbiology · 2017Review
- Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Article
- Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion.Blood · 2015Article
- Characterization of chikungunya virus induced host response in a mouse model of viral myositis.PloS one · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the presence of anticitrullinated protein Abs, although the exact targets and role of anticitrullinated protein autoimmunity in the pathogenesis of RA remain to be defined. Fibrinogen, which can be citrullinated, has recently emerged as a candidate autoantigen. To determine whether autoimmunity against fibrinogen can mediate inflammatory arthritis, we immunized a variety of common mouse strains with fibrinogen and found that DBA/1 and SJL mice developed an inflammatory and erosive arthritis. Mice with fibrinogen-induced arthritis (FIA) possess fibrinogen-reactive T cells that produce the proinflammatory cytokines IL-6, IL-17, TNF-alpha, and IFN-gamma. FIA can be adoptively transferred with either plasma or fibrinogen-specific T cells from diseased mice. Mice with FIA possess rheumatoid factor, circulating immune complexes, and anticyclic citrullinated peptide Abs, all of which are characteristic of human RA. These observations demonstrate that fibrinogen is arthritogenic in mice and that the pathogenesis of FIA is mediated by both autoantibodies and fibrinogen-reactive T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.