ArticleEukaryotic cell2010
Septins AspA and AspC are important for normal development and limit the emergence of new growth foci in the multicellular fungus Aspergillus nidulans.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- Beyond division and morphogenesis: Considering the emerging roles of septins in plasma membrane homeostasis and cell wall integrity in human fungal pathogens.PLoS pathogens · 2025Article
- Efficient production of salicylic acid through CmeR-PBiotechnology for biofuels and bioproducts · 2025Article
- A single septin from a polyextremotolerant yeast recapitulates many canonical functions of septin hetero-oligomers.Molecular biology of the cell · 2024Article
- The cell-end protein Tea4 spatially regulates hyphal branch initiation and appressorium remodeling in the blast fungusMolecular biology of the cell · 2024Article
- Regulators of the Asexual Life Cycle ofCells · 2023Review
- Review
- Insights of roles played by septins in pathogenic fungi.Virulence · 2021Review
- The Spt10 GNAT Superfamily Protein Modulates Development, Cell Cycle Progression and Virulence in the Fungal Insect Pathogen,Journal of fungi (Basel, Switzerland) · 2021Article
- Identifying Conserved GenericJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Haloadaptative Responses ofJournal of fungi (Basel, Switzerland) · 2020Article
- RNAi-Mediated Gene Silencing ofJournal of microbiology and biotechnology · 2020Article
- The Indispensable Role of Histone MethyltransferaseFrontiers in microbiology · 2019Article
- Proteome analysis reveals global response to deletion of mrflbA in Monascus ruber.Journal of microbiology (Seoul, Korea) · 2018Article
- The septins FaCdc3 and FaCdc12 are required for cytokinesis and affect asexual and sexual development, lipid metabolism and virulence in Fusarium asiaticum.Molecular plant pathology · 2017Article
- Cell Biology of Hyphal Growth.Microbiology spectrum · 2017Review
- Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus.Biochemical and biophysical research communications · 2017Article
- A Gin4-Like Protein Kinase GIL1 Involvement in Hyphal Growth, Asexual Development, and Pathogenesis in Fusarium graminearum.International journal of molecular sciences · 2017Article
- Septins Focus Cellular Growth for Host Infection by Pathogenic Fungi.Frontiers in cell and developmental biology · 2017Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Septins are cytoskeletal proteins found in fungi, animals, and microsporidia, where they form multiseptin complexes that act as scaffolds recruiting and organizing other proteins to ensure normal cell division and development. Here we characterize the septins AspA and AspC in the multicellular, filamentous fungus Aspergillus nidulans. Mutants with deletions of aspA, aspC, or both aspA and aspC show early and increased germ tube and branch emergence, abnormal septation, and disorganized conidiophores. Strains in which the native aspA has been replaced with a single copy of aspA-GFP driven by the native septin promoter or in which aspC has been replaced with a single copy of aspC-GFP driven by the native promoter show wild-type phenotypes. AspA-GFP and AspC-GFP show identical localization patterns as discrete spots or bars in dormant and expanding conidia, as rings at forming septa and at the bases of emerging germ tubes and branches, and as punctate spots and filaments in the cytoplasm and at the cell cortex. In conidiophores, AspA-GFP and AspC-GFP localize as diffuse bands or rings at the bases of emerging layers and conidial chains and as discrete spots or bars in newly formed conidia. AspA-GFP forms abnormal structures in DeltaaspC strains while AspC-GFP does not localize in DeltaaspA strains. Our results suggest that AspA and AspC interact with each other and are important for normal development, especially for preventing the inappropriate emergence of germ tubes and branches. This is the first report of a septin limiting the emergence of new growth foci in any organism.
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