ArticleGenetics2010
The power of the methods for detecting interlocus gene conversion.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Evolutionary genetic dissection of human interferons.The Journal of experimental medicine · 2011Trial
- Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification.Immunogenetics · 2026Article
- Genomic characterization ofPathogens and global health · 2026Article
- Ectopic Gene Conversion Causing Quantitative Trait Variation.Molecular biology and evolution · 2025Article
- Evolutionary Nonindependence Between Human piRNAs and Their Potential Target Sites in Protein-Coding Genes.Journal of molecular evolution · 2025Article
- Recent and Recurrent Autopolyploidization Fueled Diversification of Snow Carp on the Tibetan Plateau.Molecular biology and evolution · 2024Article
- Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland.Immunogenetics · 2024Article
- Phased chromosome-scale genome assembly of an asexual, allopolyploid root-knot nematode reveals complex subgenomic structure.PloS one · 2024Article
- NCOurd: modelling length distributions of NCO events and gene conversion tracts.Bioinformatics (Oxford, England) · 2023Article
- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Concerted evolution reveals co-adapted amino acid substitutions in NaCurrent biology : CB · 2021Article
- Genomes of Anguillid Herpesvirus 1 Strains Reveal Evolutionary Disparities and Low Genetic Diversity in the GenusMicroorganisms · 2021Article
- What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination?Frontiers in plant science · 2020Article
- Duplication history and molecular evolution of the rbcS multigene family in angiosperms.Journal of experimental botany · 2019Article
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- Gene tree species tree reconciliation with gene conversion.Journal of mathematical biology · 2019Article
- Genomic and biologic comparisons of cyprinid herpesvirus 3 strains.Veterinary research · 2018Article
- Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.Scientific reports · 2018Article
- Phylogenomic analysis demonstrates a pattern of rare and long-lasting concerted evolution in prokaryotes.Communications biology · 2018Article
- Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interlocus gene conversion can homogenize DNA sequences of duplicated regions with high homology. Such nonvertical events sometimes cause a misleading evolutionary interpretation of data when the effect of gene conversion is ignored. To avoid this problem, it is crucial to test the data for the presence of gene conversion. Here, we performed extensive simulations to compare four major methods to detect gene conversion. One might expect that the power increases with increase of the gene conversion rate. However, we found this is true for only two methods. For the other two, limited power is expected when gene conversion is too frequent. We suggest using multiple methods to minimize the chance of missing the footprint of gene conversion.
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